Tuning of fast-spiking interneuron properties by an activity-dependent transcriptional switch.
Tuning of fast-spiking interneuron properties by an activity-dependent transcriptional switch.
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DOI：
10.1126/science.aab3415
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发表时间：
2015-09-11
期刊：
影响因子：
--
通讯作者：
Marín O
中科院分区：
文献类型：
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作者：
Dehorter N;Ciceri G;Bartolini G;Lim L;del Pino I;Marín O
神经回路的功能取决于特定类别神经元的产生。神经元身份通常在神经元退出细胞周期成为有丝分裂后细胞的时间附近建立，并且通常接受的是，一旦神经元的身份已经建立，其命运在整个生命中保持不变。在这里，我们表明，网络活动动态调制快速尖峰（FS）中间神经元的属性，通过有丝分裂后表达的转录调节Er81。在成人皮质，Er81蛋白水平定义了一个频谱FS篮状细胞具有不同的属性，其相对比例，然而，不断调整响应神经元的活动。因此，我们的研究结果表明，中间神经元的属性是可塑性的成人皮质，至少在一定程度上。
The function of neural circuits depends on the generation of specific classes of neurons. Neural identity is typically established near the time when neurons exit the cell cycle to become postmitotic cells, and it is generally accepted that, once the identity of a neuron has been established, its fate is maintained throughout life. Here, we show that network activity dynamically modulates the properties of fast-spiking (FS) interneurons through the postmitotic expression of the transcriptional regulator Er81. In the adult cortex, Er81 protein levels define a spectrum of FS basket cells with different properties, whose relative proportions are, however, continuously adjusted in response to neuronal activity. Our findings therefore suggest that interneuron properties are malleable in the adult cortex, at least to a certain extent.