ASSIGNMENT OF GENES ENCODING A UNIQUE CYTOKINE (IL12) COMPOSED OF 2 UNRELATED SUBUNITS TO CHROMOSOME-3 AND CHROMOSOME-5
ASSIGNMENT OF GENES ENCODING A UNIQUE CYTOKINE (IL12) COMPOSED OF 2 UNRELATED SUBUNITS TO CHROMOSOME-3 AND CHROMOSOME-5
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DOI：
10.1016/s0888-7543(05)80283-6
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发表时间：
1992-09-01
期刊：
影响因子：
4.4
通讯作者：
WOLF, SF
中科院分区：
文献类型：
--
作者：
SIEBURTH, D;JABS, EW;WOLF, SF
IL 12（以前称为NKSF或CLMF）是一种独特的细胞因子，由两个不相关的二硫键连接的亚基组成。较大的40-kDa亚基（p40）是细胞因子受体家族的成员，较小的35-kDa亚基（p35）与IL 6和GCSF相关。这两个亚基的染色体定位通过PCR分析啮齿动物-人杂交的DNA来确定。通过PCR分析含有易位染色体的杂交种和通过分析辐射杂交种获得p40的更精确的映射。亚基映射到不同的染色体：p40（IL 12 B）到5 q31-q33和p35（IL 12 A）到3 p12 -3q13.2。
IL12 (formerly NKSF or CLMF) is a unique cytokine composed of two unrelated disulfide-linked subunits. The larger 40-kDa subunit (p40) is a member of the cytokine receptor family, and the smaller 35-kDa subunit (p35) is related to IL6 and GCSF. The chromosomal localization of these two subunits was determined by PCR analysis of DNA from rodent-human hybrids. More refined mapping was obtained by PCR analysis of hybrids containing translocation chromosomes and for p40, by analysis of radiation hybrids. The subunits map to different chromosomes: p40 (IL12B) to 5q31–q33 and p35 (IL12A) to 3p12–3q13.2.