Macromolecular organization of basement membranes
Macromolecular organization of basement membranes
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DOI：
10.1016/s0955-0674(96)80102-5
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发表时间：
1996-10-01
影响因子：
7.5
通讯作者：
Timpl, R
中科院分区：
文献类型：
--
作者：
Timpl, R
A considerable variety of basement membrane components, including in particular more than ten laminin isoforms and their novel alpha chains (alpha 3, alpha 4 and alpha 5), has been characterized in recent studies. The functional properties of these components are increasingly being analyzed by recombinant technologies and by structural studies at atomic resolution, techniques which led to the elucidation of the nidogen-binding epitope on the laminin gamma 1 chain. Novel insights into functions of basement membrane components have been obtained from gene-targeting experiments and studies of mutated genes identified in inherited disorders.
