Intentional limited pulmonary resection for peripheral T1 NO MO small-sized lung cancer
Intentional limited pulmonary resection for peripheral T1 NO MO small-sized lung cancer
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DOI：
10.1067/mtc.2003.156
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发表时间：
2003-04-01
影响因子：
6
通讯作者：
Suzuki, R
中科院分区：
文献类型：
--
作者：
Koike, T;Yamato, Y;Suzuki, R
目的：本研究旨在证明局限性肺切除治疗周围型小肺癌的疗效不亚于肺叶切除术。方法：1992~2000年9年间，CT_1~N_0~M_0周围型非小细胞肺癌中，肿瘤最大直径小于或等于2 cm的CT_1N_0~M_0周围型非小细胞肺癌患者，在诊断影像上肿瘤最大直径小于或等于2 cm时，如患者同意行肺叶切除术，则行有限切除，未经同意行肺叶切除术。比较局限切除组(74例)和肺叶切除组(159例)术后肿瘤分期为PT1、N0、M0的患者的生存期和临床转归。结果：局限性切除组包括60例节段性切除和14例楔形切除。术后平均52个月随访，局限性切除组3年和5年生存率分别为94.0%和89.1%，肺叶切除组3年和5年生存率分别为97.0%和90.1%，差异均无统计学意义。局部切除5例，肺叶切除9例，术后复发5例，两组术后复发率差异无统计学意义。结论：对于肿瘤最大直径在2 cm以下的周围型T1 N0 M0非小细胞肺癌，局限性肺切除与肺叶切除的疗效相当。
Objective: The present study was undertaken to demonstrate that limited pulmonary resection for peripheral small-sized lung cancer yields outcomes not inferior to those of lobectomy.Methods: During the 9-year period from 1992 to 2000, patients with cT1 N0 M0 peripheral non-small cell lung cancer whose maximum tumor diameter was 2 cm or less on diagnostic imaging and in whom lobectomy was determined to be feasible were treated with limited resection if the patient consented to the procedure and with lobectomy if consent to limited resection was not obtained. The survival and clinical outcome of the patients whose tumors were postoperatively staged as pT1 N0 M0 were compared between the limited resection group (n = 74) and the lobectomy group (n = 159).Results: The limited resection group consisted of 60 patients treated with segmentectomy and 14 patients treated with wedge resection. Among patients followed up for a mean period of 52 months after the operation, neither the 3-year nor 5-year survivals differed significantly between the limited resection group (3-year survival, 94.0%; 5-year survival, 89.1%) and the lobectomy group (3-year survival, 97.0%; 5-year survival, 90.1%). Postoperative tumor recurrence was noted in 5 patients after limited resection and in 9 patients after lobectomy, and the difference in the incidence of postoperative recurrence between the 2 groups was not significant.Conclusions: The results of this study indicate that in patients with peripheral T1 N0 M0 non-small cell lung cancer whose maximum tumor diameter was 2 cm or less, the outcome of limited pulmonary resection is comparable with that of pulmonary lobectomy.