Significance of tumor-associated autoantibodies in the early diagnosis of lung cancer
Significance of tumor-associated autoantibodies in the early diagnosis of lung cancer
复制标题
肿瘤相关自身抗体在肺癌早期诊断中的意义
DOI：
10.1111/crj.12769
复制
发表时间：
2018-06-01
影响因子：
1.7
通讯作者：
Wang, Qi
中科院分区：
文献类型：
--
作者：
Du, Qiang;Yu, Ruofei;Wang, Qi
目的肿瘤相关抗原（TAAs）自身抗体具有较高的特异性和稳定性，有望成为肿瘤诊断和早期发现的重要工具。本研究旨在检测肺癌患者血清中肿瘤相关自身抗体（tumor-associated autoantibodies，AAbs）的水平，探讨其在肺癌早期筛查中的应用价值397例肺部病变患者的p53、PGP9.5、SOX 2、GAGE 7、GBU 4 -5、CAGE和MAGEA 1基因表达谱其中新诊断NSCLC 305例，SCLC 47例，良性结节45例，对照组74例。结果AAbs检测组能有效区分恶性病变、良性病变和正常对照组，其敏感性为56.53%，特异性为91.60%。结合CT检查可进一步提高诊断特异性达95.80%。AAbs对恶性结节也有较高的诊断价值，有望成为一种新的判断直径小于8 mm的恶性结节的方法。根据病理，NSCLC分期，肿瘤大小，年龄或gender.ConclusionThis assay confirmed the value of AAbs Panel as a diagnosis tool combined with CT scan.
ObjectivesAutoantibodies tumor-associated antigens (TAAs) could be a valuable tool for the diagnosis or early detection of cancer due to their relatively high specificity and stability. The purpose of this study is to detect the level of tumor-associated autoantibodies in lung cancer and assess the diagnostic potential of autoantibodies in screening strategy for early stage lung cancer.Materials and MethodsLevels of tumor-associated autoantibodies (AAbs) were measured against a panel of seven TAAs (p53, PGP9.5, SOX2, GAGE7, GBU4-5, CAGE and MAGEA1) in 397 patients with pulmonary lesions (305 with newly diagnosis of NSCLC, 47 with SCLC and 45 with benign nodule) and 74 control persons without any nodules in the lung after chest MDCT scan. The sensitivity, specificity for patients and control persons, positive rate of the panel in different pathology, stage, size of lesion, age and gender were compared and analyzed.ResultsThe AAbs panel could distinguish malignant lesions from benign lesions and control people, with sensitivity of 56.53% and specificity of 91.60%. The specificity could be further increased to 95.80%, when combined with CT. The AAbs also showed high diagnostic value of malignant nodule, and it would be a new method for judgment of malignant nodules that are less than 8 mm in diameter. No significant differences were seen based on pathology, NSCLC stages, tumor size, age or gender.ConclusionThis assay confirms the value of AAbs panel as a diagnostic tool combined with CT scan.