Comparative electron-microscopic features of normal, hyperplastic, and adenomatous human colonic epithelium. II. Variations in surface architecture found by scanning electron microscopy.
Comparative electron-microscopic features of normal, hyperplastic, and adenomatous human colonic epithelium. II. Variations in surface architecture found by scanning electron microscopy.
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正常、增生和腺瘤人类结肠上皮的电子显微镜特征比较。
DOI：
10.1016/s0016-5085(19)32642-3
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发表时间：
1973
期刊：
影响因子：
29.4
通讯作者：
G. Kaye
中科院分区：
文献类型：
--
作者：
C. Fenoglio;C. Fenoglio;R. Richart;R. Richart;G. Kaye;G. Kaye
我们利用扫描电子显微镜的高分辨率和大焦深来定义正常人类结肠和人类结肠息肉的表面特征。该技术表明正常结肠的表面具有包含多个隐窝的区域化。正常结肠的表面覆盖有吸收细胞和杯状细胞。增生性息肉被过度发育的吸收细胞覆盖，正常的领土化存在但被扭曲。腺瘤性息肉覆盖着未成熟的细胞，除了绒毛状腺瘤外，表面明显不存在杯状细胞。腺瘤中的领土模式完全消失。
We have used the high resolution and the great depth of focus possible with the scanning electron microscope to define the surface features of normal human colon and human colonic polyps. This technique demonstrates that the surface of the normal colon has a territorialization which encompasses multiple crypts. The surface of the normal colon is covered with both absorptive cells and goblet cells. Hyperplastic polyps are covered with overdeveloped absorptive cells and the normal territorialization is present but is distorted. Adenomatous polyps are covered with immature cells and, except for the villous adenomas, goblet cells are strikingly absent from the surface. The territorial patterns are totally obliterated in the adenomas.