Protein-Protein Interactions: Principles, Techniques, and their Potential Role in New Drug Development
Protein-Protein Interactions: Principles, Techniques, and their Potential Role in New Drug Development
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DOI：
10.1080/07391102.2011.10508619
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发表时间：
2011-06-01
影响因子：
4.4
通讯作者：
Kumar, Raj
中科院分区：
文献类型：
--
作者：
Khan, Shagufta H.;Ahmad, Faizan;Kumar, Raj
一个巨大的基因网络通过蛋白质与蛋白质的相互作用相互连接，是生理条件下几乎所有生物过程的关键组成部分。任何生物基本网络的破坏都会导致病理状况，从而导致相关疾病。因此，对生物功能的正确理解保证了对蛋白质-蛋白质相互作用和控制这一过程的分子机制的全面了解。许多强大的技术/方法已经被开发出来，以了解这种相互作用是如何在各种生理和病理条件下发生的，这一事实突出了蛋白质-蛋白质相互作用过程的重要性。已知许多关键的蛋白质-蛋白质相互作用参与疾病相关的信号通路，并代表治疗干预的新靶点。因此，控制蛋白质-蛋白质相互作用为发现新的药物靶点提供了丰富的红利。各种研究工具的可用性和人类基因组的知识使我们处于一个独特的位置来理解高度复杂的生物网络，以及其中涉及的机制。在这篇综述文章中，我们总结了蛋白质-蛋白质相互作用网络，它们的结合/动力学参数的技术/方法，以及这些相互作用在开发潜在的药物设计工具中的作用。
A vast network of genes is inter-linked through protein-protein interactions and is critical component of almost every biological process under physiological conditions. Any disruption of the biologically essential network leads to pathological conditions resulting into related diseases. Therefore, proper understanding of biological functions warrants a comprehensive knowledge of protein-protein interactions and the molecular mechanisms that govern such processes. The importance of protein-protein interaction process is highlighted by the fact that a number of powerful techniques/methods have been developed to understand how such interactions take place under various physiological and pathological conditions. Many of the key protein-protein interactions are known to participate in disease-associated signaling pathways, and represent novel targets for therapeutic intervention. Thus, controlling protein-protein interactions offers a rich dividend for the discovery of new drug targets. Availability of various tools to study and the knowledge of human genome have put us in a unique position to understand highly complex biological network, and the mechanisms involved therein. In this review article, we have summarized protein-protein interaction networks, techniques/methods of their binding/kinetic parameters, and the role of these interactions in the development of potential tools for drug designing.