RESPONSE PROPERTIES OF LOCAL FIELD POTENTIALS AND MULTIUNIT ACTIVITY IN THE MOUSE VISUAL CORTEX
RESPONSE PROPERTIES OF LOCAL FIELD POTENTIALS AND MULTIUNIT ACTIVITY IN THE MOUSE VISUAL CORTEX
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DOI：
10.1016/j.neuroscience.2013.08.065
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发表时间：
2013-12-19
期刊：
影响因子：
3.3
通讯作者：
Engel, A. K.
中科院分区：
文献类型：
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作者：
Land, R.;Engler, G.;Engel, A. K.
细胞外局部场电位（LFPs）和多单位活动（MUA）反映了给定皮层结构中多个神经元的空间整合活动。在猫和灵长类动物的视觉皮层中，这些信号表现出对视觉刺激特征的选择性，如方向、运动方向或空间频率。在视觉神经科学中越来越多地使用的小鼠视觉皮层模型中，群体信号的视觉刺激选择性尚未被详细研究。我们记录LFP和MUA使用多电极阵列和两个衍生的措施，高通滤波连续MUA和双极的第一空间导数的LFP，在异氟烷麻醉的C57 BI/6小鼠的视觉皮层。我们分析了发病潜伏期和特征的感受野，除了方向，方向，空间和时间频率偏好的这些信号。群体信号的起始潜伏期短至30 ms，感受野大至38，MUA感受野小于LFP。所有四种群体信号都表现出相似的空间频率偏好（每度约0.1个周期）和时间频率偏好（每秒约1个周期）。然而，对于所有的人口信号，空间和频率调谐是广泛的和运动偏好的方向和方向是缺席的。视觉刺激选择性的LFPs和MUA在小鼠视觉皮层的表征应提供有关其可用性的信息，在表征刺激特性，并披露可能的限制。(C)2013作者由爱思唯尔有限公司出版。保留所有权利。
Extracellular local field potentials (LFPs) and multiunit activity (MUA) reflect the spatially integrated activity of multiple neurons in a given cortical structure. In the cat and primate visual cortices, these signals exhibit selectivity for visual stimulus features, such as orientation, direction of motion or spatial frequency. In the mouse visual cortex, a model which has been increasingly used in visual neuroscience, the visual stimulus selectivity of population signals has not been examined in detail. We recorded LFPs and MUA using multielectrode arrays and two derived measures, the high-pass filtered continuous MUA and the bipolar first spatial derivative of the LFP, in the visual cortex of isoflurane-anesthetized C57BI/6 mice. We analyzed the onset latency and characterized the receptive fields in addition to the direction, orientation, and spatial and temporal frequency preferences of these signals. Population signals exhibited onset latencies as short as 30 ms and possessed receptive fields as large as 38 with MUA receptive fields smaller than those of LFPs. All four population signals exhibited similar spatial frequency preferences (,-0.1 cycles per degree) and temporal frequency preferences (-1 cycle per second). However, for all population signals, spatial and frequency tunings were broad and orientation and direction of motion preferences were absent. The characterization of the visual stimulus selectivity of LFPs and MUA in the mouse visual cortex should provide information regarding their usability in characterizing stimulus properties and disclose possible limitations. (C) 2013 The Authors. Published by Elsevier Ltd. All rights reserved.