The biocompatibility and osteoconductivity of a cement containing β-TCP for use in vertebroplasty
The biocompatibility and osteoconductivity of a cement containing β-TCP for use in vertebroplasty
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DOI：
10.1002/jbm.a.30793
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发表时间：
2006-09-01
影响因子：
4.9
通讯作者：
Nakamura, T.
中科院分区：
文献类型：
--
作者：
Goto, K.;Shinzato, S.;Nakamura, T.
研制了一种用于经皮椎体成形术的新型复合骨水泥G2 B1。G2 B1含有β磷酸三钙颗粒和甲基丙烯酸甲酯-丙烯酸甲酯共聚物作为粉末组分，以及甲基丙烯酸甲酯、氨基甲酸酯二甲基丙烯酸酯和甲基丙烯酸四氢糠酯作为液体组分。在植入大鼠胫骨后4、8、12、26和52周，使用扫描电子显微镜、接触显微放射照相术和Giemsa表面染色评价生物相容性和骨传导性。为了评价骨传导性，计算亲和力指数（%）。扫描电子显微镜和接触显微放射照相术显示，骨与G2 B1的接触在4周内达到（亲和指数：4周时为50.2 +/- 11.8），大部分边缘在26周内达到（亲和指数：26周时为87.4 +/- 7.2）。具体而言，G2 B1通过广泛的富钙磷酸盐层接触骨，其降解在8周内开始，主要在边缘区域。Giemsa表面染色显示G2 B1周围几乎没有炎症反应。这些结果表明，G2 B1是一种生物相容性和骨传导性骨水泥。(c)2006 Wiley Periodicals，Inc.
A new composite bone cement designated "G2B1" was developed for percutaneous transpedicular vertebroplasty. G2B1 contains beta tricalcium phosphate particles and methylmethacrylate-methylacrylate copolymer as the powder components, and methylmethacrylate, urethane dimethacrylate, and tetrahydrofurfuryl methacrylate as the liquid components. Biocompatibility and osteoconductivity were evaluated using scanning electron microscopy, contact microradiography, and Giemsa surface staining 4, 8, 12, 26, and 52 weeks after implantation into rat tibiae. To evaluate osteoconductivity, affinity indices (%) were calculated. Scanning electron microscopy and contact microradiography revealed that bone contact with G2B1 was attained within 4 weeks (affinity index: 50.2 +/- 11.8 at 4 weeks) and at most of the margin within 26 weeks (affinity index: 87.4 +/- 7.2 at 26 weeks). Specifically, G2B1 contacted bone via a wide calcium-phosphate-rich layer, and its degradation started within 8 weeks, mainly in the marginal area. Giemsa surface staining showed that there was almost no inflammatory reaction around the G2B1. These results indicate that G2B1 is a biocompatible and osteoconductive bone cement. (c) 2006 Wiley Periodicals, Inc.