Increased thromboxane B2 levels are associated with lipid peroxidation and Bcl-2 expression in human lung carcinoma
Increased thromboxane B2 levels are associated with lipid peroxidation and Bcl-2 expression in human lung carcinoma
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DOI：
10.1016/j.canlet.2005.03.032
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发表时间：
2006-03-28
期刊：
影响因子：
9.7
通讯作者：
Yim, APC
中科院分区：
文献类型：
--
作者：
Chen, GG;Lee, TW;Yim, APC
关于同时研究血栓素A（2）（TXA（2））脂质过氧化和Bcl-2这三种癌症相关因子以及分析它们在肺癌中的关系的信息很少。本研究旨在探讨52例非小细胞肺癌（NSCLC）组织中血栓素A 2（TXA 2）的稳定代谢产物血栓素B 2（TXB 2）、脂质过氧化及Bcl-2表达的变化。与非肿瘤组织相比，肺肿瘤组织中的硫代巴比妥酸反应物质（TBARS）水平（脂质过氧化反应的指标）显著升高。肿瘤组织中TXB_2明显高于非肿瘤组织。有趣的是，吸烟者的样本中TXB 2的浓度高于不吸烟者。Bcl-2在肿瘤组织中的表达明显高于非肿瘤组织。肿瘤组织中TXB 2和TBARS也呈正相关;晚期癌症的TXB 2水平较高。这一发现支持TXB 2可能在促进肿瘤生长中起作用的观点。总之，我们的研究表明，TXB 2的生产增加，在肺肿瘤组织中，这种增加可以导致脂质过氧化，这可能是由Bcl-2的表达升高满足。(c)2005爱思唯尔爱尔兰有限公司保留所有权利。
There is little information regarding simultaneous investigations of thromboxane A(2) (TXA(2)) lipid peroxidation and Bcl-2, three cancer-related agents, and analyses of their relationships in lung cancer. The present study was to study thromboxane B, (TXB2), a stable metabolite of TXA2, lipid peroxidation and Bcl-2 expression in 52 non-small cell lung carcinoma (NSCLC) tissue samples. The level of thiobarbituric acid reactive substances (TBARS), an index for lipid peroxidation was significantly increased in the lung tumor tissues, compared with non-tumor tissues. TXB2 was much higher in the tumor tissues than non-tumor tissues. Interestingly, the concentration of TXB2 in samples from those who smoked was higher than that from those who did not smoke. The expression of Bcl-2 was significantly elevated in the tumor tissues, compared to the non-tumor tissues. There was also a positive correlation between TXB2 and TBARS in tumor tissues; advanced stage cancers had higher levels of TXB2. This finding supports the idea that TXB2 may have a role in promoting tumor growth. In conclusion, our study demonstrates that the production of TXB2 is increased in lung tumor tissues and that Such an increase can result in lipid peroxidation which may be met by an elevation in Bcl-2 expression. (c) 2005 Elsevier Ireland Ltd. All rights reserved.