Rapid Diagnostic Testing for SARS-CoV-2.
Rapid Diagnostic Testing for SARS-CoV-2.
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DOI：
10.1056/nejmcp2117115
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发表时间：
2022-01-20
期刊：
影响因子：
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通讯作者：
Drain PK
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文献类型：
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作者：
Drain PK
临床要点SARS-CoV-2的快速诊断检测食品药品监督管理局授权用于诊断严重急性呼吸综合征冠状病毒2的快速诊断检测（RDTs）（SARS-CoV-2）感染的核酸扩增测试检测基因或基于抗原的免疫测定检测SARS-CoV-2的蛋白质。RDTs被批准用于有冠状病毒疾病症状的人2019（COVID-19）和无症状者（与COVID-19患者密切接触或处于潜在高风险传播环境中）。有症状者应尽快接受检测，在等待检测结果期间隔离，如果RDT呈阴性，则考虑重新检测，特别是如果他们有很高的预测试感染概率。无症状的人与已知的接触SARS-CoV-2应接受测试后5至7天，如果RDT呈阴性，则应在2天后再次进行检测。已知接触过SARS-CoV-2但未完全接种疫苗的人员应在等待检测结果期间进行隔离，检测呈阳性的人员应隔离，联系医疗保健提供者或公共卫生部门，并告知密切接触者有关感染的情况。
Key Clinical PointsRapid Diagnostic Testing for SARS-CoV-2Rapid diagnostic tests (RDTs) that are authorized by the Food and Drug Administration to diagnose severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are either nucleic acid amplification tests to detect genes or antigen-based immunoassays to detect proteins of SARS-CoV-2.RDTs are approved for use in persons with symptoms of coronavirus disease 2019 (Covid-19) and in asymptomatic persons who are close contacts of a person with Covid-19 or who have been in a potential high-risk transmission setting.Symptomatic persons should undergo testing as soon as possible, quarantine while awaiting test results, and consider retesting if they have a negative RDT, particularly if they have a high pretest probability of infection.Asymptomatic persons with a known exposure to SARS-CoV-2 should undergo testing 5 to 7 days after exposure, and if the RDT is negative, they should undergo testing again 2 days later.Persons with a known exposure to SARS-CoV-2 who are not fully vaccinated should quarantine while awaiting test results, and persons who test positive should isolate, contact a health care provider or public health department, and inform close contacts about the infection.