Role of Asymmetrical Dimethylarginine in Inflammation-Induced Endothelial Dysfunction in Human Atherosclerosis
Role of Asymmetrical Dimethylarginine in Inflammation-Induced Endothelial Dysfunction in Human Atherosclerosis
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DOI：
10.1161/hypertensionaha.110.168245
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发表时间：
2011-07-01
期刊：
影响因子：
8.3
通讯作者：
Stefanadis, Christodoulos
中科院分区：
文献类型：
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作者：
Antoniades, Charalambos;Demosthenous, Michael;Stefanadis, Christodoulos
我们探讨了不对称二甲基精氨酸（ADMA）作为全身炎症诱导的内皮功能障碍的原因的作用。体外数据表明，ADMA的生物利用度受促炎刺激的调节，但目前尚不清楚ADMA是否是人类炎症和内皮功能障碍之间的联系。在研究1中，我们招募了351名冠状动脉疾病（CAD）患者和87名健康对照。在研究2中，我们招募了69名CAD，69名健康人和10名类风湿性关节炎患者，而在研究3中，22名健康人和70名CAD受试者被随机分配到伤寒沙门氏菌疫苗接种组（n = 11名健康人和n=60名CAD）或安慰剂组（n=11名健康人和n=10名CAD）。在0和8小时测量循环白细胞介素6/ADMA和血流介导的扩张（FMD）。在研究1中，健康个体和CAD患者的ADMA与FMD呈负相关（P
We explored the role of asymmetrical dimethylarginine (ADMA) as a cause of endothelial dysfunction induced by systemic inflammation. In vitro data suggest that ADMA bioavailability is regulated by proinflammatory stimuli, but it is unclear whether ADMA is a link between inflammation and endothelial dysfunction in humans. In study 1 we recruited 351 patients with coronary artery disease (CAD) and 87 healthy controls. In study 2 we recruited 69 CAD, 69 healthy, and 10 patients with rheumatoid arthritis, whereas in study 3, 22 healthy and 70 CAD subjects were randomly assigned to Salmonella typhii vaccination (n=11 healthy and n=60 CAD) or placebo (n=11 healthy and n=10 CAD). Circulating interleukin 6/ADMA and flow-mediated dilation (FMD) were measured at 0 and 8 hours. In study 1, ADMA was inversely correlated with FMD in healthy individuals and CAD patients (P