Potential role of the estrogen receptor gene (ESR1) in anxiety
Potential role of the estrogen receptor gene (ESR1) in anxiety
复制标题
DOI：
10.1038/sj.mp.4000503
复制
发表时间：
1999-07-01
影响因子：
11
通讯作者：
MacMurray, JP
中科院分区：
文献类型：
--
作者：
Comings, DE;Muhleman, D;MacMurray, JP
除了神经递质，通过血流作用的激素也在行为中发挥作用，为了测试激素受体遗传变异的潜在贡献，我们在179名接受药物滥用治疗的成年男性中，研究了雌激素受体1基因(ESR1)二核苷酸重复的等位基因与SCL-90的九个子分和总分之间的关联。根据重复序列长度可能直接影响基因调控的假设，将等位基因分为短等位基因(S)和长等位基因(L)，在CU值小于或等于0.05时，SS、LS和LL3个等位基因与症状自评量表的焦虑、恐怖和总症状得分的方差分析显示显著相关。其中，焦虑分数在邦费罗尼校正后的cu小于或等于0.005时仍然显着。经回归分析，ESR1基因可解释焦虑评分变异的7%(P<0.0004)。这些结果与ESR1基因在人类行为中的作用是一致的。由于女性的雌激素水平比男性高得多，这可能解释了女性焦虑频率增加的原因。
In addition to neurotransmitters, hormones, acting through the blood stream, also play a role in behavior, To test the potential contribution of genetic variations in hormone receptors we have examined the association between the alleles of the dinucleotide repeat of the estrogen receptor 1 gene (ESR1) and the nine subscores and total score of the SCL-90 in a group of 179 adult males treated for substance abuse. Based on our prior hypothesis that the length of repeat polymorphisms may play a direct role in gene regulation, the alleles were divided into two groups, short (S) and long (L), ANOVA of the SS, LS, and LL genotypes showed a significant association at cu less than or equal to 0.05 for three of the SCL-90 scores: anxiety, phobic anxiety, and total symptoms. Of these the anxiety score remained significant at a Bonferroni corrected cu of less than or equal to 0.005. By regression analysis, the ESR1 gene accounted for 7% of the variance of the anxiety score (P less than or equal to 0.0004). These results are consistent with a role of the ESR1 gene in human behavior. Since estrogen levels are much higher in women than men, this could account for the increased frequency of anxiety in women.