Changing Perspectives on the Strategic Use of Microwave Heating in Organic Synthesis
Changing Perspectives on the Strategic Use of Microwave Heating in Organic Synthesis
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DOI：
10.1002/tcr.201700044
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发表时间：
2018-03-01
期刊：
影响因子：
6.6
通讯作者：
Stiegman, A. E.
中科院分区：
文献类型：
--
作者：
Dudley, Gregory B.;Stiegman, A. E.
本个人报告描述了对有机化学中伪微波效应的合作调查。微波辅助有机合成的研究一直充满了困惑、争议和错误信息。微波加热对于有机合成无疑是一种有用的策略，但它是否能提供战略优势，在许多人心中仍然是一个悬而未决的问题。（具有讽刺意味的是，那些不认为这是一个开放问题的人，对于它是否得到了肯定或消极的解决，意见分歧。）我们在这一领域的研究是由微波加热可以改变反应动力学的方式不同于传统加热下观察到的假设指导的。在这里，我们简要地记录了我们的兴趣来源，我们最初的疑问和相关的争议，以及最近为识别，量化和开始利用选择性微波加热在有机合成中的战略优势所做的努力。
This Personal Account describes collaborative investigations into apocryphal microwave effects in organic chemistry. Focused research on microwave-assisted organic synthesis has been fraught with confusion, controversy, and misinformation. Microwave heating is an undoubtedly useful tactic for organic synthesis, but whether or not it can offer strategic advantages remains an open question in the minds of many people. (Ironically, those who do not consider it an open question are split as to whether it has been resolved affirmatively or negatively.) Our research in this area is guided by the hypothesis that microwave heating can alter reaction kinetics in ways distinct from what is observable under conventional heating. Here we provide a succinct record of the origins of our interests, our initial queries and associated controversies, and recent efforts to identify, quantify, and begin to leverage selective microwave heating for strategic advantage in organic synthesis.