A PERIPHERAL MONONEUROPATHY IN RAT THAT PRODUCES DISORDERS OF PAIN SENSATION LIKE THOSE SEEN IN MAN
A PERIPHERAL MONONEUROPATHY IN RAT THAT PRODUCES DISORDERS OF PAIN SENSATION LIKE THOSE SEEN IN MAN
复制标题
DOI：
10.1016/0304-3959(88)90209-6
复制
发表时间：
1988-04-01
期刊：
影响因子：
7.4
通讯作者：
XIE, YK
中科院分区：
文献类型：
--
作者：
BENNETT, GJ;XIE, YK
在成年大鼠中，通过在总坐骨神经周围放置松弛的收缩性结扎来产生外周单神经病。这些大鼠的术后行为表明产生了痛觉过敏、异常性疼痛和可能的自发性疼痛（或感觉迟钝）。术后第二天对有害辐射热的痛觉过敏反应明显，并持续2个月以上。对化学性疼痛的痛觉过敏反应也存在。从站在无害的冷金属地板上或无害的机械刺激诱发的伤害性反应以及大鼠坚持将后爪保持在警戒位置来推断异常性疼痛的存在。自发性疼痛的存在是由食欲抑制和明显自发的疼痛反应的频繁发生所提示的。在大约三分之一的大鼠中，受影响的后爪异常温暖或凉爽。大约有一半的老鼠在患侧出现了严重过度生长的爪子。用这种动物模型进行的实验可能会促进我们对人类神经病理性疼痛疾病的神经机制的理解。
A peripheral mononeuropathy was produced in adult rats by placing loosely constrictive ligatures around the common sciatic nerve. The postoperative behavior of these rats indicated that hyperalgesia, allodynia and, possibly, spontaneous pain (or dysesthesia) were produced. Hyperalgesic responses to noxious radiant heat were evident on the second postoperative day and lasted for over 2 months. Hyperalgesic responses to chemogenic pain were also present. The presence of allodynia was inferred from the nocifensive responses evoked by standing on an innocuous, chilled metal floor or by innocuous mechanical stimulation, and by the rats'' persistence in holding the hind paw in a guarded position. The presence of spontaneous pain was suggested by a suppression of appetite and by the frequent occurrence of apparently spontaneous nocifensive responses. The affected hind paw was abnormally warm or cool in about one-third of the rats. About one-half of the rats developed grossly overgrown claws on the affected side. Experiments with this animal model may advance our understanding of the neural mechanisms of neuropathic pain disorders in humans.