Resegmentation is an ancestral feature of the gnathostome vertebral skeleton
Resegmentation is an ancestral feature of the gnathostome vertebral skeleton
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DOI：
10.7554/elife.51696
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发表时间：
2020-02-24
期刊：
影响因子：
7.7
通讯作者：
Gillis, J. Andrew
中科院分区：
文献类型：
--
作者：
Criswell, Katharine E.;Gillis, J. Andrew
脊椎骨骼是脊椎动物的一个决定性特征。然而，脊椎分割的模式在主要谱系之间变化很大。在四足动物中，相邻的体节通过“重新分割”的过程重组形成一个椎骨。在硬骨鱼，有相当大的混合之间的细胞的前和后体节的一半，没有明确的重新分割。为了确定是否resegmentation是一个四足动物的新奇，或有颌脊椎动物的祖先特征，我们测试了体节和椎骨之间的关系，在软骨鱼，滑冰（Leucoraja erinacea）。使用细胞谱系追踪，我们发现，冰鞋躯干椎骨出现通过四足动物样的再分割，与前和后半部分的每个椎骨来自相邻的体节。我们进一步表明，尾椎骨也出现通过重新分割，虽然与每个身体节的椎骨数量的重复。这些研究结果解决了作为一个祖先的功能，颌骨脊椎动物身体计划轴重新分割。
The vertebral skeleton is a defining feature of vertebrate animals. However, the mode of vertebral segmentation varies considerably between major lineages. In tetrapods, adjacent somite halves recombine to form a single vertebra through the process of 'resegmentation'. In teleost fishes, there is considerable mixing between cells of the anterior and posterior somite halves, without clear resegmentation. To determine whether resegmentation is a tetrapod novelty, or an ancestral feature of jawed vertebrates, we tested the relationship between somites and vertebrae in a cartilaginous fish, the skate (Leucoraja erinacea). Using cell lineage tracing, we show that skate trunk vertebrae arise through tetrapod-like resegmentation, with anterior and posterior halves of each vertebra deriving from adjacent somites. We further show that tail vertebrae also arise through resegmentation, though with a duplication of the number of vertebrae per body segment. These findings resolve axial resegmentation as an ancestral feature of the jawed vertebrate body plan.