Peroxisome proliferator-activated receptor γ gene locus is related to body mass index and lipid values in healthy nonobese subjects
Peroxisome proliferator-activated receptor γ gene locus is related to body mass index and lipid values in healthy nonobese subjects
复制标题
DOI：
10.1161/01.atv.19.12.2940
复制
发表时间：
1999-12-01
影响因子：
8.7
通讯作者：
Luft, FC
中科院分区：
文献类型：
--
作者：
Knoblauch, H;Busjahn, A;Luft, FC
过氧化物酶体增殖物激活受体γ（PPAR γ）基因与病态肥胖有关，对脂质和碳水化合物代谢很重要。然而，健康非肥胖受试者中基因变异的相关性尚未确定。我们招募了同卵和异卵的健康非肥胖双胞胎受试者来检验这一假设，即在健康非肥胖受试者中，PPAR γ基因对体重指数和脂质浓度很重要。对同一双卵双生子采用连锁和关联策略，结果显示，PPARgamma基因位点连锁（P
The peroxisome proliferator-activated receptor gamma (PPAR gamma) gene has been implicated in morbid obesity and is important to lipid and carbohydrate metabolism. However, the relevance of gene variations in healthy nonobese subjects has not been defined. We recruited monozygotic and dizygotic healthy nonobese twin subjects to test the hypothesis that the PPAR gamma gene is important to body mass index and lipid concentrations in healthy nonobese subjects. Both linkage and association strategies were used in the same dizygotic twins, The PPAR gamma gene locus was linked (P