The relationship between angiotensin converting enzyme gene I/D polymorphism and QT dispersion in patients with hypertrophic cardiomyopathy
The relationship between angiotensin converting enzyme gene I/D polymorphism and QT dispersion in patients with hypertrophic cardiomyopathy
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DOI：
10.1177/1470320310368190
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发表时间：
2010-09-01
影响因子：
2.9
通讯作者：
Erol, Cetin
中科院分区：
文献类型：
--
作者：
Kaya, Cansin Tulunay;Gurlek, Adalet;Erol, Cetin
简介：肥厚型心肌病（HCM）以心肌结构紊乱为特征，可引起室性心律失常和猝死。血管紧张素转换酶（ACE）有两个缺失等位基因（DD基因型）已被提出与心肌胶原含量增加。本研究应用QT离散度（QTd）技术对HCM患者和正常对照组的三种不同ACE基因型的心室复极的区域性差异进行了研究。采用12导联心电图测量QT间期。用聚合酶链反应（PCR）方法从外周血提取的DNA中确定ACE基因型。结果：HCM组和对照组的中位年龄相似。与对照组相比，HCM组的QT离散度和校正QT离散度（QT离散度）明显更大。两组各基因型频率相似。结论：HCM患者QTd和QTcd均增高，其中DD基因型者更为明显。
Introduction: Hypertrophic cardiomyopathy (HCM) is characterized by disorganized myocardial architecture, and may cause ventricular arrhythmias and sudden death. The angiotensin-converting enzyme (ACE) with two deletion alleles (DD genotype) has been proposed to be associated with increased myocardial collagen content. We evaluated QT dispersion (QTd), which reflects regional differences in ventricular repolarization, in HCM patient and controls among the three different ACE genotypes.Materials and methods: Sixty-three patients with HCM and 20 healthy subjects were included in the study. QT parameters were measured from 12 lead electrocardiograms. ACE genotypes were determined from the DNA extracted from peripheral blood by a polymerase chain reaction (PCR) method. QT parameters were compared among the three ACE genotypes both in HCM patients and controls.Results: Median ages were similar in HCM and control groups. QTd and corrected QTd (QTcd) were significantly greater in the HCM group compared with the controls. The frequencies of each genotype were similar in both groups. Although QTd and QTcd did not differ among the three genotypes in the control subjects, they were significantly greater in patients with DD genotype compared with other genotypes in the HCM group.Conclusion: QTd and QTcd are increased in patients with HCM, especially in those with the DD genotype.