Late-life exercise mitigates skeletal muscle epigenetic aging.
Late-life exercise mitigates skeletal muscle epigenetic aging.
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晚年运动减轻骨骼肌表观遗传衰老。
DOI：
10.1111/acel.13527
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发表时间：
2022-01
期刊：
影响因子：
7.8
通讯作者：
Watowich SJ
中科院分区：
文献类型：
--
作者：
Murach KA;Dimet-Wiley AL;Wen Y;Brightwell CR;Latham CM;Dungan CM;Fry CS;Watowich SJ
即使在晚年进行肌肉锻炼，也有功能上的好处，但表观遗传因素对晚年运动适应的贡献尚不清楚。利用简化代表性亚硫酸盐测序、核糖体DNA和线粒体特异性甲基化检测、靶向高分辨率甲基化分析、DNAGE™表观遗传衰老时钟分析以及可翻译的小鼠自愿耐力/耐力运动训练(渐进加权车轮跑，功率)模型，我们提供了运动可以缓解骨骼肌表观遗传衰老的证据。22-24个月龄的晚年能力适度但显著地减弱了与年龄相关的向启动子超甲基化的转变。动力训练了8周的老年小鼠肌肉的表观遗传年龄大约比24个月大的久坐不动的小鼠年轻8周，这代表了小鼠预期寿命的8%。这些数据为运动作为一种延缓骨骼肌衰老的疗法提供了分子基础。老年小鼠(22-24个月大)接受自愿的大容量肥大运动训练刺激(渐进性加权轮跑，或功率)后，骨骼肌中的DNA甲基化年龄较低，总体甲基化状况更年轻。
There are functional benefits to exercise in muscle, even when performed late in life, but the contributions of epigenetic factors to late‐life exercise adaptation are poorly defined. Using reduced representation bisulfite sequencing (RRBS), ribosomal DNA (rDNA) and mitochondrial‐specific examination of methylation, targeted high‐resolution methylation analysis, and DNAge™ epigenetic aging clock analysis with a translatable model of voluntary murine endurance/resistance exercise training (progressive weighted wheel running, PoWeR), we provide evidence that exercise may mitigate epigenetic aging in skeletal muscle. Late‐life PoWeR from 22–24 months of age modestly but significantly attenuates an age‐associated shift toward promoter hypermethylation. The epigenetic age of muscle from old mice that PoWeR‐trained for eight weeks was approximately eight weeks younger than 24‐month‐old sedentary counterparts, which represents ~8% of the expected murine lifespan. These data provide a molecular basis for exercise as a therapy to attenuate skeletal muscle aging. Aged mice (22‐24 months old) subjected to a voluntary high‐volume hypertrophic exercise training stimulus (progressive weighted wheel running, or PoWeR) had a lower DNA methylation age in skeletal muscle, as well as a more youthful overall methylation profile.
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DOI：
10.1002/jcsm.12741
发表时间：
2021-08
期刊：
Journal of cachexia, sarcopenia and muscle
影响因子：
--
作者：
Voisin S;Jacques M;Landen S;Harvey NR;Haupt LM;Griffiths LR;Gancheva S;Ouni M;Jähnert M;Ashton KJ;Coffey VG;Thompson JM;Doering TM;Gabory A;Junien C;Caiazzo R;Verkindt H;Raverdy V;Pattou F;Froguel P;Craig JM;Blocquiaux S;Thomis M;Sharples AP;Schürmann A;Roden M;Horvath S;Eynon N
通讯作者：
Eynon N
全基因组甲基化谱揭示了人类衰老速度的定量观点。
影响因子：
16
作者：
Hannum, Gregory;Guinney, Justin;Zhao, Ling;Zhang, Li;Hughes, Guy;Sadda, SriniVas;Klotzle, Brandy;Bibikova, Marina;Fan, Jian-Bing;Gao, Yuan;Deconde, Rob;Chen, Menzies;Rajapakse, Indika;Friend, Stephen;Ideker, Trey;Zhang, Kang
通讯作者：
Zhang, Kang
影响因子：
5.5
作者：
Figueiredo, Vandre C.;Wen, Yuan;von Walden, Ferdinand
通讯作者：
von Walden, Ferdinand
小鼠 Timm8a1 基因的移码突变导致大脑中线粒体结构异常，与听力和记忆障碍相关
影响因子：
4
作者：
Song，Pingping;Guan，Yuqing;Hu，Yafang
通讯作者：
Hu，Yafang
影响因子：
7.7
作者：
Ubaida-Mohien, Ceereena;Lyashkov, Alexey;Ferrucci, Luigi
通讯作者：
Ferrucci, Luigi