High prevalence of thymic tissue in adults with human immunodeficiency virus-1 infection
High prevalence of thymic tissue in adults with human immunodeficiency virus-1 infection
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DOI：
10.1172/jci2834
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发表时间：
1998-06-01
影响因子：
15.9
通讯作者：
Grant, RM
中科院分区：
文献类型：
--
作者：
McCune, JM;Loftus, R;Grant, RM
感染HIV-1的成年人的胸腺通常被认为是不活跃的，这是因为与年龄相关的退化和病毒破坏。我们重新审视了成人胸腺功能的问题，使用胸部计算机断层扫描（CT）测量HIV-1血清阳性（n = 99）或HIV-1血清阴性（n = 32）受试者的胸腺组织，并将这些结果与循环CD 4（+）和CD 8（+）T细胞的水平相关联，这些T细胞在表型上被描述为幼稚胸腺迁出者。在许多（47/99）HIV-1血清阳性的20-59岁成人中可检测到丰富的胸腺组织。与年龄无关，胸腺组织的放射学表现与较高的CD 4（+）T细胞计数显著相关，（P = 0.02）和较高的百分比和绝对数量的循环初治（CD 45 RA + CD 62 L+）CD 4（+）T细胞（P < 0.04），在HIV-1血清阳性的年轻成人中，在CD 4计数在300-500个细胞/μ l范围内的老年受试者（小于或等于39岁）和不考虑CD 4计数的老年受试者（> 40岁）中（P = 0.03）。这些研究表明，胸腺在一些但不是所有的HIV-1疾病成年人中是有功能的。
The thymus in adults infected with the HIV-1 is generally thought to be inactive, both because of age-related involution and viral destruction. We have revisited the question of thymic function in adults, using chest-computed tomography (CT) to measure thymic tissue in HIV-l-seropositive (n = 99) or HIV-l-seronegative (n = 32) subjects, and correlating these results with the level of circulating CD4(+) and CD8(+) T cells that are phenotypically described as naive thymic emigrants. Abundant thymic tissue was detectable in many (47/99) HIV-l-seropositive adults, aged 20-59. Independent of age, radiographic demonstration of thymic tissue was significantly associated with both a higher CD4(+) T cell count (P = 0.02) and a higher percentage and absolute number of circulating naive (CD45RA+CD62L+) CD4(+) T cells (P < 0.04), The prevalence of an abundant thymus was especially high in younger HIV-l-seropositive adults (less than or equal to 39 yr) with CD4 counts in the range 300-500 cells/mu l and in older subjects (> 40 yr) regardless of CD4 count (P = 0.03). These studies suggest that the thymus is functional in some but not all adults with HIV-1 disease.