Context-Dependent Sensory Processing across Primary and Secondary Somatosensory Cortex
Context-Dependent Sensory Processing across Primary and Secondary Somatosensory Cortex
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DOI：
10.1016/j.neuron.2020.02.004
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发表时间：
2020-05-06
期刊：
影响因子：
16.2
通讯作者：
Chen, Jerry L.
中科院分区：
文献类型：
--
作者：
Condylis, Cameron;Lowet, Eric;Chen, Jerry L.
为了解释环境，我们的大脑必须根据过去经验的内部表征来评估外部刺激。初级（S1）和次级（S2）体感觉皮层如何根据最近的经验处理刺激尚不清楚。利用投射神经元的同时多区域群体成像和局部光遗传失活，我们研究了小鼠执行基于须的工作记忆任务。我们发现，反映当前刺激的活动、对先前刺激的回忆（提示回忆）和刺激类别分布在S1和S2上。尽管存在重叠表征，S2对于处理提示回忆反应并将这些反应传递给S1很重要。S2的网络特性与S1不同，S2持续编码被动条件下的记忆和刺激类别。虽然这两个区域都编码刺激类别，但只有S1中的信息通过不一定包括S2的通路对任务表现重要。这些发现揭示了S1和S2在情境依赖性感觉加工中的分布和分离作用。
To interpret the environment, our brain must evaluate external stimuli against internal representations from past experiences. How primary (S1) and secondary (S2) somatosensory cortices process stimuli depending on recent experiences is unclear. Using simultaneous multi-area population imaging of projection neurons and focal optogenetic inactivation, we studied mice performing a whisker-based working memory task. We find that activity reflecting a current stimulus, the recollection of a previous stimulus (cued recall), and the stimulus category are distributed across S1 and S2. Despite this overlapping representation, S2 is important for processing cued recall responses and transmitting these responses to S1. S2 network properties differ from S1, wherein S2 persistently encodes cued recall and the stimulus category under passive conditions. Although both areas encode the stimulus category, only information in S1 is important for task performance through pathways that do not necessarily include S2. These findings reveal both distributed and segregated roles for S1 and S2 in context-dependent sensory processing.