Surface modification of polymers by plasma treatments for the enhancement of biocompatibility and controlled drug release
Surface modification of polymers by plasma treatments for the enhancement of biocompatibility and controlled drug release
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DOI：
10.1016/j.surfcoat.2013.02.042
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发表时间：
2013-10-25
影响因子：
5.4
通讯作者：
Hotta, A.
中科院分区：
文献类型：
--
作者：
Yoshida, S.;Hagiwara, K.;Hotta, A.
聚合物已广泛应用于生物医学领域，如医疗器械、组织工程支架、药物输送系统的药物载体等。将聚合物用于此类医疗器械应该是完全明智的，因为聚合物通常非常柔软，成本效益高，并且相对生物相容。为了促进聚合物的生物相容性的进一步发展，以增强材料的使用，聚合物表面的功能化已经被有意地引入。等离子体改性是聚合物表面处理的最有效方法之一，因为等离子体处理可以选择性地改变聚合物表面的化学和物理性质，而不影响聚合物的原始体积特性。此外，与其他表面改性方法相比，等离子体表面改性提供更短的处理时间。当等离子体施加到聚合物表面时，无论聚合物表面粗糙度是否发生变化，都会引入官能团、接枝聚合、涂层和分子交联形成。通过等离子体改性得到的高功能化聚合物将有效地用于组织工程材料或药物释放系统。本文综述了几种等离子体处理聚合物的制备和表征方法，并介绍了它们在药物释放系统和组织工程材料中的应用。(C)2013爱思唯尔有限公司版权所有。
Polymers have been widely used for biomedical purposes such as medical devices, tissue engineering scaffolds, and drug carriers for drug delivery system (DDS). Using polymers for such medical devices should be entirely sensible, as polymers are generally very soft, highly cost-effective, and relatively biocompatible. In order to encourage further development in the biocompatibility of the polymers for the enhanced use of the materials, the functionalization of the polymer surfaces has been deliberately introduced. Plasma modification is one of the most efficient ways for the surface treatment of polymers, since plasma treatment could selectively modify the chemical and the physical properties of the surface of the polymers by not affecting the original bulk characteristics of the polymers. Also, plasma surface modification offers shorter treatment time as compared with other surface modification methods. When plasma was applied to the polymer surface, functional groups, graft polymerization, coatings, and molecular crosslinking formation would be introduced with or without the change in the surface roughness of the polymer. The highly functionalized polymers by the plasma modifications would be effectively used for the materials in tissue engineering or drug delivery systems. In this paper, the fabrication and the characterization of polymers by several types of plasma treatments are reviewed, followed by the introduction of their applications to the materials in drug delivery systems and tissue engineering. (C) 2013 Elsevier B.V. All rights reserved.