The effect of chlorhexidine/xylitol chewing-gum on cariogenic salivary microflora: a clinical trial in elderly patients.
The effect of chlorhexidine/xylitol chewing-gum on cariogenic salivary microflora: a clinical trial in elderly patients.
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洗必太/木糖醇口香糖对致龋唾液微生物群的影响：老年患者的临床试验。
DOI：
10.1159/000262382
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发表时间：
1997
期刊：
影响因子：
4.2
通讯作者：
Beatrix Jones
中科院分区：
文献类型：
--
作者：
D. Simons;E. Kidd;David Beighton;Beatrix Jones
在53名参与这项随机、双盲、安慰剂对照试验的受试者（平均年龄79.49 ± 7.7岁）中，测定了14天使用氯己定/木糖醇或木糖醇口香糖对唾液中变形链球菌、乳酸杆菌和酵母菌水平的影响。唾液流速和牙釉质染色进行了测量和口香糖咀嚼的受试者的态度进行了评估，通过使用结构化的问卷。洗必泰/木糖醇口香糖显著降低唾液中变形链球菌（p < 0.0001）、乳酸杆菌（p < 0.05）和酵母菌（p < 0.05）的水平，而木糖醇安慰剂口香糖仅显著降低变形链球菌（p < 0.01）。研究人群发现，每天嚼两次口香糖，每次10分钟，是接受药物治疗和改善口腔健康的可接受方法。在使用口香糖之前，参与者认识到口干的持续症状，并且他们对口干的主观评价与具有口干副作用的处方药物的数量显著相关（p < 0.001）。继续使用口香糖的愿望与受试者在基线时对口腔干燥的评估以及他们从口香糖使用中获得的口腔健康显著相关。只有那些基线时牙釉质染色的参与者在使用氯己定/木糖醇口香糖后才表现出牙釉质染色增加。
The effects of 14-day use of either a chlorhexidine/xylitol or a xylitol chewing gum on salivary levels of mutans streptococci, lactobacilli, and yeasts were determined for 53 subjects (mean age 79.49 +/- 7.7 years) participating in this randomised, double-blind, placebo-controlled trial. Salivary flow rates and enamel staining were measured and the attitudes of the subjects to gum chewing were evaluated by the use of structured questionnaires. The chlorhexidine/xylitol gum significantly reduced the salivary levels of mutans streptococci (p < 0.0001) lactobacilli (p < 0.05) and yeasts (p < 0.05) while the xylitol placebo gum produced significant reductions in mutans streptococci (p < 0.01) only. The study population found chewing gum twice per day for 10 min an acceptable method of receiving medication and improving oral health. Prior to gum use participants recognised persistent symptoms of dry mouth and their subjective evaluation of dry mouth was significantly (p < 0.001) related to the number of prescribed medications with xerostomic side-effects. The desire to continue gum use was significantly related to the subjects' evaluation of their oral dryness at baseline and to their perceived oral health gain from gum usage. Only those participants with stained enamel at baseline exhibited increased enamel staining following chlorhexidine/xylitol gum usage.