Activation time imaging in the presence of myocardial ischemia: Choice of initial estimates for iterative solvers
Activation time imaging in the presence of myocardial ischemia: Choice of initial estimates for iterative solvers
复制标题
心肌缺血时的激活时间成像：迭代求解器初始估计的选择
DOI：
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发表时间：
2012
期刊：
影响因子：
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通讯作者：
O. Dossel
中科院分区：
文献类型：
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作者：
W. Schulze;D. Potyagaylo;O. Dossel
在这项工作中，进行模拟研究，演示如何激活时间的心脏动作电位可以重建体表电位图（BSPM）。在受心肌缺血或坏死影响的心室中模拟期外收缩，并计算相关的BSPM。初始估计是需要迭代算法，解决相关的非线性重建问题。作为一个良好的初始估计是必不可少的一个适当的重建，两种方法的鲁棒性进行了测试，对病理条件的影响：临界时间的方法和线性时间积分为基础的方法。虽然第一种方法在本研究中将激活时间外推到非活性组织中，但后者将缺血或坏死组织划分为均匀区域。展望未来，提出了两种方法相结合的概念.
In this work, a simulation study is performed that demonstrates how activation times of cardiac action potentials can be reconstructed from body surface potential maps (BSPMs). An extrasystole is simulated in the ventricles, which are affected by myocardial ischemia or necrosis, and the related BSPM is calculated. Initial estimates are required for iterative algorithms that solve the related non-linear reconstruction problem. As a good initial estimate is essential for a proper reconstruction, the robustness of two methods is tested against the influence of pathological conditions: the critical times method and a linear timeintegral based method. While the first method extrapolates activation times into inactive tissue in this study, the latter carves out ischemic or necrotic tissue as homogeneous regions. In an outlook, a concept for the combination of both methods is proposed.