PC4: A new regulator of cyclin D1 transcript levels.
PC4: A new regulator of cyclin D1 transcript levels.
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PC4：细胞周期蛋白 D1 转录水平的新调节因子。
DOI：
10.1083/jcb.202401056
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发表时间：
2024
期刊：
影响因子：
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通讯作者：
Sicinski,Piotr
中科院分区：
文献类型：
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作者：
Fassl,Anne;Sicinski,Piotr
细胞周期蛋白的表达在细胞周期中受到严格的调控，以允许精确地激活细胞周期蛋白依赖的激酶。在这一期中，潘等人。(https://doi.org/10.1083/jcb.202308066)发现了一种核糖核酸结合蛋白PC4，它是肝细胞癌细胞中细胞周期蛋白D1mRNA稳定性的调节因子。这项研究提供了一种新的机制来调节人类细胞中一种关键的细胞周期蛋白Cyclin D1的水平。
The expression of cyclin proteins is tightly regulated during the cell cycle, to allow precise activation of cyclin-dependent kinases. In this issue, Pan et al. (https://doi.org/10.1083/jcb.202308066) identify an RNA-binding protein, PC4, as a regulator of cyclin D1 mRNA stability in hepatocellular carcinoma cells. This study provides a new mechanism regulating the levels of a key cell cycle protein, cyclin D1, in human cells.