Long-chain polyunsaturated fatty acids at birth and cognitive function at 7y of age
Long-chain polyunsaturated fatty acids at birth and cognitive function at 7y of age
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DOI：
10.1038/sj.ejcn.1601506
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发表时间：
2003-01-01
影响因子：
4.7
通讯作者：
Hornstra, G
中科院分区：
文献类型：
--
作者：
Bakker, EC;Ghys, AJA;Hornstra, G
目的：在中枢神经系统（CNS）生长突增期间，长链多不饱和脂肪酸（LCPUFA）快速积累。这尤其涉及二十二碳六烯酸（DHA，22:6n-3）和花生四烯酸（AA，20:4n-6），它们被认为在中枢神经系统发育和功能中发挥重要作用。本研究的目的是调查 7 岁时的认知表现与脐静脉血浆磷脂（代表产前脂肪酸可用性）和 7 岁时血浆磷脂中的 LCPUFA 水平之间的关系。 设计：作为后续研究的一部分，使用考夫曼儿童评估系统对 306 名足月出生的儿童在 7 岁时的认知表现进行了评估。采用向后逐步回归分析来研究结果与 LCPUFA 状态之间的关系。社会阶层、母亲智力和养育技能等被纳入协变量。 结果：结果显示，DHA 或 AA 与出生时以及 7 岁时的认知表现没有显着相关性。 7 岁时的 LCPUFA 水平也与这些结果无关。与文献一致，认知结果测量与母亲教育、母亲智力和孩子出生体重之间存在显着关系。结论：总而言之，我们的结果并没有提供证据证明 7 岁时的认知表现与出生时或 7 岁时的 LCPUFA 状态之间存在正相关。 赞助：马斯特里赫特大学医院（Profileringsfonds：财务支持）和荷兰瓦赫宁根皇家 Numico（随访时对血液样本进行盲法脂肪酸分析）。
Objective: During the central nervous system (CNS) growth spurt, rapid accretion of long chain polyunsaturated fatty acids (LCPUFA) takes place. This particularly concerns docosahexaenoic acid (DHA, 22:6n-3) and arachidonic acid (AA, 20:4n-6), which are thought to play important roles in CNS development and function. The aim of this study was to investigate the relationship between cognitive performance at 7y of age and LCPUFA levels in umbilical venous plasma phospholipids, representing the prenatal fatty acid availability, and in plasma phospholipids sampled at 7y.Design: As part of a follow-up study, the cognitive performance of 306 children, born at term, was assessed at 7y of age with the Kaufman Assessment Battery for Children. Backward stepwise regression analysis was used to study the relationship between the outcomes and LCPUFA status. Social class, maternal intelligence and parenting skills were included as covariables, among others.Results: Results show no significant association with either DHA or AA at birth and the cognitive performance at 7 y of age. The LCPUFA levels at 7y were not associated with these outcomes either. Consistent with the literature, significant relationships were found between cognitive outcome measures and maternal education, maternal intelligence and the child's birthweight. Conclusions: In conclusion, our results do not provide evidence for a positive association between cognitive performance at 7y and LCPUFA status at birth or at 7y of age.Sponsorship: University Hospital Maastricht (Profileringsfonds: financial support) and Royal Numico, Wageningen, The Netherlands (blinded fatty acid analyses of the blood samples at follow-up).