Regeneration potential and mechanism of bone marrow mesenchymal stem cell transplantation for treating intervertebral disc degeneration
Regeneration potential and mechanism of bone marrow mesenchymal stem cell transplantation for treating intervertebral disc degeneration
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DOI：
10.1007/s00776-010-1536-3
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发表时间：
2010-11
影响因子：
1.7
通讯作者：
Yun-tao Wang;Xiao-Tao Wu;Feng Wang
中科院分区：
文献类型：
--
作者：
Yun-tao Wang;Xiao-Tao Wu;Feng Wang
椎间盘退变是下背痛的主要原因，具有很高的社会成本。椎间盘退变的病理机制在很大程度上是未知的。基于细胞的治疗，特别是使用骨髓间充质干细胞作为移植种子，虽然仍处于起步阶段，但已被证明是一种有前途的，现实的椎间盘再生方法。本文综述了骨髓间充质干细胞治疗椎间盘退变的体内外研究进展，并讨论了干细胞移植治疗椎间盘退变的最新再生机制。
Intervertebral disc degeneration is a primary cause of low back pain and has a high societal cost. The pathological mechanism by which the intervertebral disc degenerates is largely unknown. Cell-based therapy especially using bone marrow mesenchymal stem cells as seeds for transplantation, although still in its infancy, is proving to be a promising, realistic approach to intervertebral disc regeneration. This article reviews current advances regarding regeneration potential in both the in vivo and vitro studies of bone marrow mesenchymal stem cell-based therapy and discusses the up-to-date regeneration mechanisms of stem cell transplantation for treating intervertebral disc degeneration.