Whole genome microarray analysis of growth hormone-induced gene expression in bone: T-box3, a novel transcription factor, regulates osteoblast proliferation
Whole genome microarray analysis of growth hormone-induced gene expression in bone: T-box3, a novel transcription factor, regulates osteoblast proliferation
复制标题
DOI：
10.1152/ajpendo.00592.2005
复制
发表时间：
2006-07-01
影响因子：
5.1
通讯作者：
Mohan, Subburaman
中科院分区：
文献类型：
--
作者：
Govoni, Kristen E.;Lee, Seong Keun;Mohan, Subburaman
全基因组微阵列分析骨中生长激素诱导的基因表达：T-box 3，一种新的转录因子，调节成骨细胞增殖美国生理学内分泌代谢杂志291：E128-E136，2006年。首次出版于2006年2月7日; doi：10.1152/ajpendo. 00592.2005.-生长激素（GH）在骨的发育和维持中是重要的;然而，所涉及的IGF依赖性和非依赖性分子途径仍有待建立。我们使用微阵列分析来评估4周龄GH缺陷小鼠在治疗后6或24 h单次注射GH（4 mg/kg体重）或PBS（n = 6/组）后的GH信号通路。6160个基因在P
Whole genome microarray analysis of growth hormone-induced gene expression in bone: T-box3, a novel transcription factor, regulates osteoblast proliferation. Am J Physiol Endocrinol Metab 291: E128-E136, 2006. First published February 7, 2006; doi: 10.1152/ajpendo. 00592.2005.-Growth hormone (GH) is important in the development and maintenance of bone; however, the IGF-dependent and -independent molecular pathways involved remain to be established. We used microarray analysis to evaluate GH signaling pathways in 4-wk-old GH-deficient mice following a single injection of GH (4 mg/kg body wt) or PBS (n = 6/group) at 6 or 24 h after treatment. Six thousand one hundred sixty genes were differentially expressed at P