Infection with two genotypes of Epstein-Barr virus in an infant with AIDS and lymphoma of the central nervous system.
Infection with two genotypes of Epstein-Barr virus in an infant with AIDS and lymphoma of the central nervous system.
复制标题
患有艾滋病和中枢神经系统淋巴瘤的婴儿感染两种基因型的 Epstein-Barr 病毒。
DOI：
10.1093/infdis/153.3.601
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Miller,G
中科院分区：
文献类型：
--
作者：
Katz,BZ;Andiman,WA;Eastman,R;Martin,K;Miller,G
如果儿童中的一个或两个属于高危人群，如双性恋者、静脉注射吸毒者、血友病患者、接受输血的人和海地人，儿童可能会患上艾滋病[1，2]。虽然大多数患有艾滋病的儿童都有EB病毒抗体，但人们对这些儿童EBV感染的性质及其临床后果知之甚少[1]。EB病毒相关性淋巴增生性疾病在某些免疫缺陷状态的患者中很常见，例如与器官移植相关的患者[3]。患有艾滋病的成年人患上了与EB病毒相关的伯基特淋巴瘤[4]。最近，我们发现艾滋病儿童的淋巴细胞性间质性肺炎与EBV[4a]有关。病毒也可能在青少年艾滋病特有的高丙种球蛋白血症和多克隆B细胞激活中发挥作用[5]我们对一名患有艾滋病的婴儿进行了两年多的前瞻性跟踪调查，他患上了EBV相关的淋巴瘤，最先在中枢神经系统发现。我们对婴儿及其母亲的病毒学研究构成了本报告的基础。这些研究表明，婴儿进行性EBV感染的性质存在一些惊人的异常。
Children may develop AIDS if one or both of their par-ents fall into a high-risk group, such as bisexuals, iv drug abusers, hemophiliacs, recipients of blood transfusions, and Haitians [1, 2]. Although most children with AIDS have antibodies to Epstein-Barr virus (EBV), little is known about the nature of the EBV infections and their clinical consequences in these children [1]. EBV-associated lymphoproliferative disease is common in patients with cer-tain immunodeficiency states, such as that associated with organ transplants [3]. Adults with AIDS have developed EBV-associated Burkitt's lymphoma [4]. Recently we found that lymphocytic interstitial pneumonitis in children with AIDS is associated with EBV [4a]. The virus may also play a role in the hypergammaglobulinemia and polyclonal B cell activation that are so characteristic of juvenile AIDS [5]We have prospectively followed, over a period of two years, an infant with AIDS who developed an EBV-associated lymphoma that was detected first in the CNS. Our virological study of the infant and his mother form the basis of this report. These studies demonstrated a number of striking abnormalities in the nature of the progressive EBV infection in the infant.