Rab proteins of the endoplasmic reticulum: functions and interactors
Rab proteins of the endoplasmic reticulum: functions and interactors
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DOI：
10.1042/bst20120158
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发表时间：
2012-12-01
影响因子：
3.9
通讯作者：
Simmen, Thomas
中科院分区：
文献类型：
--
作者：
Sandoval, Carolina Ortiz;Simmen, Thomas
然而，我们今天所知道的Rab家族的Ras相关的小GTP酶的大部分来源于对高尔基体复合体，内体和质膜运输的观察，Rab的一个子集部分或主要定位于ER（内质网）。在这里，Rabs如Rab 1、Rab 2、Rab 6和Rab 33可以调节囊泡在高尔基复合体、ERGIC（ER-高尔基中间室）和ER本身之间的顺行和逆行运输。然而，在ER相关的Rabs中，一些Rabs似乎发挥与贩运不直接相关的作用：这些Rabs（例如Rab 32或Rab 24）可以帮助atlastin和reticulon家族的蛋白质确定ER微管的范围和方向。在这样做的过程中，这些Rab不仅调节ER与其他细胞器如线粒体的接触，而且还调节自噬体的形成。
Whereas most of what we know today about the Ras-related small GTPases of the Rab family stems from observations made on Golgi complex, endosome and plasma membrane trafficking, a subset of Rabs localizes in part or predominantly to the ER (endoplasmic reticulum). Here, Rabs such as Rab1, Rab2, Rab6 and Rab33 can regulate the anterograde and retrograde trafficking of vesicles between the Golgi complex, the ERGIC (ER-Golgi intermediate compartment) and the ER itself. However, among the ER-associated Rabs, some Rabs appear to perform roles not directly related to trafficking: these Rabs (e.g. Rab32 or Rab24) could aid proteins of the atlastin and reticulon families in determining the extent and direction of ER tubulation. In so doing, these Rabs regulate not only ER contacts with other organelles such as mitochondria, but also the formation of autophagosomes.