Successful co-administration of a human rotavirus and oral poliovirus vaccines in Bangladeshi infants in a 2-dose schedule at 12 and 16 weeks of age
Successful co-administration of a human rotavirus and oral poliovirus vaccines in Bangladeshi infants in a 2-dose schedule at 12 and 16 weeks of age
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DOI：
10.1016/j.vaccine.2008.12.059
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发表时间：
2009-02-25
期刊：
影响因子：
5.5
通讯作者：
Bock, H. L.
中科院分区：
文献类型：
--
作者：
Zaman, K.;Sack, D. A.;Bock, H. L.
对口服减毒活人轮状病毒疫苗 RIX4414 (Rotarix (TM)) 和口服脊髓灰质炎疫苗 (OPV) 的联合施用进行了评估。健康婴儿随机接受 2 剂： RIX4414 或安慰剂与 OPV 联合给药（12 周和 16 周龄）；或 RIX4414 或安慰剂在 OPV 后 15 天给药。接种疫苗后，56.5-66.7% 的 RIX4414 和 18.6% 安慰剂接受者出现轮状病毒 IgA 血清转化。在联合给予或不联合给予 OPV 的 RIX4414 组之间没有观察到显着差异。脊髓灰质炎血清保护仪式各组之间没有观察到统计学上的显着差异。 RIX4414 疫苗与 OPV 共同接种时具有免疫原性，并且不会干扰 OPV 血清保护率。 (C) 2009 Elsevier Ltd. 保留所有权利。
Co-administration of oral live-attenuated human rotavirus vaccine RIX4414 (Rotarix (TM)) and oral polio vaccine (OPV) was assessed. Healthy infants were randomised to receive 2-doses of either: RIX4414 or placebo co-administered with OPV (12 and 16 weeks of age): or RIX4414 or placebo given 15 days after OPV. After vaccination, 56.5-66.7% of RIX4414 and 18.6% of placebo recipients had seroconverted for rotavirus IgA. No significant differences between RIX4414 groups with or without OPV co-administration were observed. No statistically significant differences were observed between groups for polio seroprotection rites. RIX4414 vaccine was immunogenic when co-administered with OPV and did not interfere with OPV seroprotection rates. (C) 2009 Elsevier Ltd. All rights reserved.