Triterpenoids from the Fruits and Leaves of the Blackberry (Rubus allegheniensis) and Their Inhibitory Activities on Foam Cell Formation in Human Monocyte-Derived Macrophage
Triterpenoids from the Fruits and Leaves of the Blackberry (Rubus allegheniensis) and Their Inhibitory Activities on Foam Cell Formation in Human Monocyte-Derived Macrophage
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黑莓 (Rubus allegheniensis) 果实和叶子中的三萜类化合物及其对人单核细胞源性巨噬细胞泡沫细胞形成的抑制活性
DOI：
10.1080/14786419.2014.939087
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
T. Nohara
中科院分区：
文献类型：
--
作者：
M. Ono;S. Yasuda;H. Komatsu;Y. Fujiwara;M. Takeya;T. Nohara
从黑莓（Rubus allegheniensisPort.）果实的甲醇提取物中，从紫菀中分离得到4个三萜类化合物-- pomolic acid（1），tormentic acid（2），euscaphic acid（3）和1β-hydroxyeuscaphic acid（4），6个三萜类化合物--2，3，myrianthic acid（5），紫菀苷II（6），丝绢酸（7）和19-hydroxy-2，3-secours-12-ene-2，3，28-三酸3-甲酯（8）-从该植物叶子的甲醇提取物中获得。根据光谱数据确定了它们的结构。在50 μM浓度下，检测化合物1 - 8对乙酰化低密度脂蛋白诱导的人单核细胞衍生的巨噬细胞中泡沫细胞形成的抑制活性。其中1个化合物的抑菌活性最强，抑菌率达90%。2 - 8的抑菌活性分别为30%、32%、33%、4%、48%、4%和24%。进一步研究了这些化合物的构效关系。
From the methanol extract of the fruits of the blackberry (Rubus allegheniensisPort.), four triterpenoids – pomolic acid (1), tormentic acid (2), euscaphic acid (3) and 1β-hydroxyeuscaphic acid (4) – were isolated, while six triterpenoids –2,3, myrianthic acid (5), ziyu glycoside II (6), sericic acid (7) and 19-hydroxy-2,3-secours-12-ene-2,3,28-trioic acid 3-methyl ester (8) – were obtained from the methanol extract of the leaves of this plant. Their structures were determined on the basis of spectral data. Compounds1–8were examined for their inhibitory activities on foam cell formation in human monocyte-derived macrophages induced by acetylated low-density lipoproteins at a 50 μM concentration. Among the tested compounds,1showed the strongest activity, with the inhibitory effect being 90%. The inhibitory activities of2–8were evaluated to be 30%, 32%, 33%, 4%, 48%, 4% and 24%, respectively. Further, the structure–activity relationship of these compounds was investigated.