α-Glucosidase Inhibitors from the Fungus Aspergillus terreus 3.05358
α-Glucosidase Inhibitors from the Fungus Aspergillus terreus 3.05358
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来自真菌土曲霉 3.05358 的 α-葡萄糖苷酶抑制剂
DOI：
10.1002/cbdv.201500027
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发表时间：
2015-11-01
影响因子：
2.9
通讯作者：
Zhan, Zha-Jun
中科院分区：
文献类型：
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作者：
Shan, Wei-Guang;Wu, Zhao-Ying;Zhan, Zha-Jun
从真菌地曲霉3.05358的培养液中分离鉴定出一种新的双酮哌嗪类生物碱amauroamine B(1)、三种已知的牛皮萜类化合物austalides B(2)、austalides N和O（3和4）以及两种已知的甾体（5和6）。它们的结构被广泛的光谱技术所阐明，包括二维核磁共振和质谱分析，单晶x射线衍射分析明确了1的绝对构型。对所有菌株进行了抑菌效果评价。与阳性对照阿卡波糖相比，Amauromine B(1)和austalide N(3)表现出更强的a-葡萄糖苷酶抑制活性。
One new diketopiperazine alkaloid amauromine B (1), along with three known meroterpenoids, austalide B (2), austalides N and O (3 and 4), and two known steroids (5 and 6), was isolated and identified from the culture broth of the fungus Aspergillus terreus 3.05358. Their structures were elucidated by extensive spectroscopic techniques, including 2D-NMR and MS analysis, the absolute configuration of 1 was unambiguously established by single crystal X-ray diffraction analysis. All the isolates were evaluated for their inhibitory effects on a-glucosidase. Amauromine B (1) and austalide N (3) exhibited more potent a-glucosidase inhibitory activities than the positive control acarbose.