Covariance of personality, neurocognition, and schizophrenia spectrum traits in the community.
Covariance of personality, neurocognition, and schizophrenia spectrum traits in the community.
复制标题
社区中人格、神经认知和精神分裂症谱系特征的协方差。
DOI：
10.1016/0920-9964(92)90045-7
复制
发表时间：
1992
影响因子：
4.5
通讯作者：
Eaton,WW
中科院分区：
文献类型：
--
作者：
Tien,AY;Costa,PT;Eaton,WW
临床研究人员在精神分裂症患者的亲属中观察到与精神分裂症的精神病理相似的异常人格特征。在包括注意力和执行能力在内的脑功能测量与这些人格精神病理学之间的相关性中，观察到进一步的相似性。然而，两个方法学因素可能解释了这些“精神分裂症谱系”人格特征和脑功能测量的共变。临床选择偏差（伯克森偏差）可能导致具有重叠条件的受试者更有可能被研究，而正常的人格属性可能影响神经行为任务的表现。本研究探讨了精神分裂症的神经行为相关因素、临床精神分裂症谱人格特征与人格五因素模型中正常人格维度的关系。为了避免Berkson偏倚，从巴尔的摩流行病学集水区调查社区样本中招募了具有高概率谱特征的受试者。大约40%的样本被发现有DSM-IIIR分裂型、分裂样或偏执型人格特征或障碍。精神分裂症谱系特征与五因素模型的人格维度显著相关，尤其是开放性和神经质。在普通的线性回归模型中，在调整了一些正常人格特征后，分裂型人格特征仍然与威斯康星卡片分类测验（WCST）的持久性反应密切相关。在逻辑回归模型中，具有分裂型、分裂样或偏执特征的受试者在正常人格特征和WCST表现方面存在差异。
Clinical researchers have observed in relatives of schizophrenic individuals abnormal personality traits resembling the psychopathology of schizophrenia. Further similarities have been observed in correlations between measures of brain function, including attention and executive abilities, and these personality psychopathologies. However, two methodologic factors might account for the covariation of these ‘schizophrenia spectrum’ personality traits and measures of brain function. Clinical selection bias (Berkson's bias) might result in subjects with overlapping conditions being more likely to be studied, and normal personality attributes could affect performance on neurobehavioral tasks. This study investigated relationships between neurobehavioral correlates of schizophrenia, clinical schizophrenia spectrum personality traits, and normal personality dimensions in the five-factor model of personality. To avoid Berkson's bias, subjects expected to have a high probability of spectrum traits were recruited from the Baltimore Epidemiologic Catchment Area Survey community sample. About 40% of the sample were found to have DSM-IIIR Schizotypal, Schizoid, or Paranoid Personality Traits or Disorders. Schizophrenia Spectrum traits showed significant associations with personality dimensions of the five factor model, particularly Openness to Experience and Neuroticism. In ordinary linear regression models, after adjustment for a number of normal personality characteristics, Schizotypal Personality Traits were still strongly associated with perseverative responses on the Wisconsin Card Sorting Test (WCST). In logistic regression models, subjects with Schizotypal, Schizoid, or Paranoid Traits differed in terms of normal personality profiles and WCST performance.