Familial aggregation of hypertension treatment and control in the genetic epidemiology network of arteriopathy (GENOA) study
Familial aggregation of hypertension treatment and control in the genetic epidemiology network of arteriopathy (GENOA) study
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DOI：
10.1016/j.amjmed.2003.12.032
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发表时间：
2004-05-15
影响因子：
5.9
通讯作者：
Turner, ST
中科院分区：
文献类型：
--
作者：
Daniels, PR;Kardia, SLR;Turner, ST
目的：评估高血压的治疗和控制是否聚集在家庭中。方法：动脉病遗传流行病学网络(Genoa)研究在1997-1999年间登记了兄弟姐妹，包括来自密西西比州杰克逊的1329名高血压非西班牙裔黑人(1057对兄弟姐妹)，来自明尼苏达州罗切斯特的1133名高血压非西班牙裔白人(859对兄弟姐妹)，以及来自德克萨斯州斯塔尔县的752名高血压拉美裔白人(627对兄弟姐妹)。高血压意识和药物治疗是在检查时确定的；控制是根据血压水平<；140/90 mm Hg来确定的。结果：总体上，90.5%的受试者知道他们的高血压，90.6%的知晓者接受了降压药治疗，56.0%的受试者高血压得到了控制。高血压治疗的优势比[OR]=1.6 1，95%可信区间[CI]：1.25~2.47；P<0.003；而控制药物治疗高血压的优势比[OR]=1.5 1；95%CI：1.5 5~1.81；P<；0.0001。结论：高血压的治疗和控制集中在家庭。(C)2004年，由Excerpta Medica Inc.
PURPOSE: To assess if the treatment and control of hypertension aggregates in families.METHODS: The Genetic Epidemiology Network of Arteriopathy (GENOA) study enrolled sibships between 1997 and 1999, including 1329 hypertensive non-Hispanic blacks (1057 sibling pairs) from Jackson, Mississippi, 1133 hypertensive non-Hispanic whites (859 sibling pairs) from Rochester, Minnesota, and 752 hypertensive Hispanic whites (627 sibling pairs) from Starr County, Texas. Hypertension awareness and drug treatment were ascertained at examination; control was defined by blood pressure levels < 140/90 mm Hg. As a measure of familial aggregation, odds ratios were calculated to assess concordance between sibling pairs in the treatment and control of hypertension.RESULTS: Overall, 90.5% of subjects were aware of their hypertension; 90.6% of those who were aware were treated with antihypertensive drugs and 56.0% of those treated had their hypertension controlled. There was statistically significant sib-sib concordance in the treatment of hypertension (odds ratio [OR] = 1.61; 95% confidence interval [Cl]: 1.25 to 2.47; P 0.003) and in the control of drug-treated hypertension (OR 1.51; 95% Cl: 1.25 to 1.81; P < 0.0001).CONCLUSION: These findings suggest that the treatment and control of hypertension aggregates in families. (C) 2004 by Excerpta Medica Inc.