Circadian clocks, diets and aging.
Circadian clocks, diets and aging.
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DOI：
10.3233/nha-160006
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发表时间：
2017-03-31
影响因子：
--
通讯作者：
Kondratov R
中科院分区：
文献类型：
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作者：
Chaudhari A;Gupta R;Makwana K;Kondratov R
饮食和喂养方案影响生物体中的许多生理系统，并可能有助于发展或预防各种病理学，包括心血管疾病或代谢综合征。一些饮食模式，如热量限制，有许多有据可查的积极代谢作用，以及延长不同生物体寿命的潜力。最近，生物钟被提出作为热量限制机制的组成部分。生物钟在行为、生理和新陈代谢中产生昼夜节律;昼夜节律的破坏与健身能力降低和寿命缩短有关。在这里，我们集中在最近的进展之间的相互作用的生物钟和饮食模式。我们讨论了如何通过喂养/营养素调节昼夜节律钟和调节营养信号通路的时钟可能有助于热量限制对代谢和寿命的有益影响，以及昼夜节律系统是否可以用于未来的医学应用。
Diets and feeding regimens affect many physiological systems in the organism and may contribute to the development or prevention of various pathologies including cardiovascular diseases or metabolic syndromes. Some of the dietary paradigms, such as calorie restriction, have many well-documented positive metabolic effects as well as the potential to extend longevity in different organisms. Recently, the circadian clocks were put forward as integral components of the calorie restriction mechanisms. The circadian clocks generate the circadian rhythms in behavior, physiology, and metabolism; circadian disruption is associated with reduced fitness and decreased longevity. Here we focus on recent advances in the interplay between the circadian clocks and dietary paradigms. We discuss how the regulation of the circadian clocks by feeding/nutrients and regulation of nutrient signaling pathways by the clocks may contribute to the beneficial effects of calorie restriction on metabolism and longevity, and whether the circadian system can be engaged for future medical applications.