Profiles of antinuclear antibodies in systemic rheumatic diseases.
Profiles of antinuclear antibodies in systemic rheumatic diseases.
复制标题
系统性风湿性疾病中抗核抗体的概况。
作者：
D. Notman;N. Kurata;E. Tan
研究了系统性红斑狼疮、类风湿性关节炎、Sjögren综合征、进行性系统性硬化症、皮肌炎、盘状红斑狼疮和混合性结缔组织病患者不同抗核抗体的流行情况。Sm抗原抗体（一种核酸性蛋白）在系统性红斑狼疮患者血清中几乎全部存在，提示该抗体可能是该病的“标记”抗体。然而，针对天然DNA和核核糖核蛋白的抗体在多种系统性风湿病中被发现。在系统性红斑狼疮中，对天然DNA的抗体呈高滴度，而在其他风湿病中呈低滴度。除混合性结缔组织病综合征外，其他系统性风湿病也有核核糖核蛋白抗体。这些研究表明，在某些系统性风湿病中存在不同的抗核抗体谱，其特征是某些抗体的存在或不存在以及它们的平均滴度的差异。
The prevalence of different antinuclear antibodies was examined in systemic lupus erythematosus, rheumatoid arthritis, Sjögren's syndrome, progressive systemic sclerosis, dermatomyositis, discoid lupus erythematosus, and mixed connective tissue disease. Antibody to Sm antigen (a nuclear acidic protein) was found almost exclusively in serums of patients with systemic lupus erythematosus, suggesting that this antibody might be a "marker" antibody for this disease. However, antibodies to native DNA and to nuclear ribonucleoprotein were found in a variety of systemic rheumatic diseases. In systemic lupus erythematosus, antibody to native DNA was present in high titer but in other rheumatic diseases in low titer. Antibody to nuclear ribonucleoprotein occurred in certain other systemic rheumatic diseases besides the mixed connective tissue disease syndrome. These studies showed that there were distinct profiles of antinuclear antibodies in certain systemic rheumatic diseases, characterized by the presence or absence of certain antibodies and by differences in their mean titers.