Plasma cortisol and corticosterone concentrations in the golden hamster, (Mesocricetus auratus).
Plasma cortisol and corticosterone concentrations in the golden hamster, (Mesocricetus auratus).
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金仓鼠（Mesocricetus auratus）的血浆皮质醇和皮质酮浓度。
DOI：
10.1016/0024-3205(85)90188-2
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发表时间：
1985
期刊：
影响因子：
6.1
通讯作者：
B. Natelson
中科院分区：
文献类型：
--
作者：
J. Ottenweller;W. Tapp;J. M. Burke;B. Natelson
由于最近对仓鼠肾上腺皮质功能的一些研究依赖于可能不充分或被误解的较早的研究，因此本研究在几种条件下重新检查了仓鼠的血浆皮质酮和皮质醇浓度，以确定哪种血浆糖皮质激素在该动物中占主导地位。采用灵敏放射免疫法分别测定基础状态、促肾上腺皮质激素（ACTH）治疗后、急性应激后和慢性应激后两种糖皮质激素的水平。在基础条件下，皮质酮浓度比皮质醇浓度高 3-4 倍。刺激后，这种差异消失了，但仓鼠的皮质醇水平很少高于皮质酮水平。 ACTH 和急性应激都会升高血浆皮质酮和皮质醇浓度，但只有慢性应激后血浆皮质醇浓度才会升高。慢性应激后皮质醇和皮质酮浓度之间的分离表明仓鼠体内的两种糖皮质激素可能是独立调节的。数据还表明，在评估仓鼠的肾上腺皮质功能时，应测量皮质酮和皮质醇。
Because some recent studies of hamster adrenocortical function have depended on older studies that may have been inadequate or misinterpreted, the present study re-examined plasma corticosterone and cortisol concentrations in hamsters under several conditions to determine which plasma glucocorticoid predominated in this animal. Sensitive radioimmunoassays were used to measure separately the two glucocorticoids in the basal condition, after adrenocorticotropin (ACTH) treatment, after acute stress, and after chronic stress. In the basal condition, corticosterone concentrations were 3–4 times higher than those of cortisol. After stimulation, this difference disappeared, but rarely were any hamster's cortisol levels higher than their corticosterone levels. Both ACTH and acute stress elevated plasma corticosterone and cortisol concentrations, but only plasma cortisol concentrations were elevated following chronic stress. The dissociation between cortisol and corticosterone concentrations after chronic stress suggests that the two glucocorticoid hormones in the hamster may be regulated independently. The data also indicate that both corticosterone and cortisol should be measured when assessing adrenocortical function in the hamster.