The biochemistry of antioxidants revisited.
The biochemistry of antioxidants revisited.
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DOI：
10.1177/011542650201700105
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发表时间：
2002-02-01
期刊：
影响因子：
--
通讯作者：
Clark, Susan F
中科院分区：
文献类型：
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作者：
Clark, Susan F
氧化应激、抗氧化营养素和慢性疾病之间的生化关系是复杂的，往往是相互矛盾的。基础研究支持这一概念，即活性氧沉淀导致脂质、蛋白质和DNA生物分子氧化损伤的变化。氧化应激与癌症、心血管疾病、糖尿病、败血症、各种眼病和神经系统疾病的发展有关。补充抗氧化营养素似乎可以抵消氧化应激的影响，但这些营养素的首选传递方式可能是通过患者的饮食，而不是作为饮食的补充剂。事实上，越来越多的证据支持每天至少吃5份水果和蔬菜。为了更好地理解抗氧化营养素在促进或预防疾病中的作用，本文将讨论与氧化应激和抗氧化防御系统相关的基本营养生物化学，然后讨论代谢（维生素E， C, a）和选定抗氧化营养素的相互关系。
Biochemical relationships between oxidative stress, antioxidant nutrients, and chronic diseases are complicated and often conflicting. Basic research supports the concept that reactive oxygen species precipitate changes that result in oxidative damage to lipid, protein, and DNA biomolecules. Oxidative stress is implicated in the development of cancer, cardiovascular disease, diabetes, sepsis, various eye diseases, and neurologic conditions. Supplementation with antioxidant nutrients seems plausible to counter the effects of oxidative stress, but the preferred mode of delivery for these nutrients may be through the patient's diet rather than as supplements to the diet. In fact, evidence supporting consumption of at least 5 servings of fruits and vegetables continues to grow. To better understand the role of antioxidant nutrients in disease promotion or prevention, this review will discuss basic nutritional biochemistry relating to oxidative stress and antioxidant defense systems, followed by a discussion of the metabolism (vitamins E, C, A) and interrelationships of select antioxidant nutrients.