Allogeneic Platelet-Rich Plasma Therapy as an Effective and Safe Adjuvant Method for Chronic Wounds
Allogeneic Platelet-Rich Plasma Therapy as an Effective and Safe Adjuvant Method for Chronic Wounds
复制标题
同种异体富血小板血浆疗法作为慢性伤口有效且安全的辅助方法。
DOI：
10.1016/j.jss.2019.09.019
复制
发表时间：
2020-02-01
影响因子：
2.2
通讯作者：
Liu, Hong-Wei
中科院分区：
文献类型：
--
作者：
Liao, Xuan;Liang, Jun-Xian;Liu, Hong-Wei
背景资料：富血小板血浆（PRP）可促进难治性创面的愈合，其在创面修复领域的应用越来越受到重视。然而，当病人的条件是非常差的，它可能是难以提供全血收获自体PRP.Methods：我们评估了在该领域的慢性难治性伤口修复异体PRP的疗效和安全性。2014年1月至2018年1月期间，60例慢性伤口患者（39例男性和21例女性，57 ± 10岁）入组了这项前瞻性、随机、单中心研究。他们的伤口得到了标准护理。根据清创后伤口中是否存在同种异体PRP，将慢性难治性伤口患者分别分为同种异体PRP治疗组和对照组。通过从健康个体收集全血和两步离心制备同种异体PRP。临床效果进行了评估，通过直观观察伤口的条件和客观评估伤口surfaces.Results：治疗30天后，同种异体PRP治疗组显示鲜红色肉芽，流血的容易减少炎性渗出。未观察到排斥反应。同种异体PRP治疗组的慢性伤口愈合速度明显快于对照组。结论：本研究表明，标准护理和同种异体PRP联合治疗慢性伤口显著缩短愈合时间，表明同种异体PRP是一种有效、安全的慢性伤口辅助治疗方法。(C)2019爱思唯尔公司All rights reserved.
Background: Platelet-rich plasma (PRP) improves the healing of refractory wounds, and its application is receiving more attention in the field of wound repair. However, when a patient's condition is very poor, it may be difficult to provide whole blood to harvest autologous PRP.Methods: We evaluated the efficacy and safety of allogeneic PRP in the field of chronic refractory wound repair. Sixty patients (39 males and 21 females, 57 +/- 10 y old) with chronic wounds were enrolled in this prospective, randomized, single-center study during January 2014 to January 2018. Their wounds were treated by standard care. The patients with chronic refractory wounds were divided into allogeneic PRP treatment and control groups on the basis of the presence or absence of allogeneic PRP in wounds after debridement, respectively. Allogeneic PRP was prepared by collecting whole blood from healthy individuals and two-step centrifugation. Clinical effects were evaluated by visually observing wound conditions and objectively assessing wound surfaces.Results: After 30 d of treatment, the allogeneic PRP-treated group showed bright red granulation that bled easily with reduced inflammatory exudation. No rejection reactions were observed. The rate of chronic wound healing was much faster in the allogeneic PRP-treated group than that in the control group.Conclusions: The present study shows that combined treatment of chronic wounds by standard care and allogeneic PRP significantly shortens healing time, suggesting that allogeneic PRP is an effective, safe adjuvant treatment for chronic wounds. (C) 2019 Elsevier Inc. All rights reserved.