Perceived stress and reported cognitive symptoms among Georgia patients with systemic lupus erythematosus.
Perceived stress and reported cognitive symptoms among Georgia patients with systemic lupus erythematosus.
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DOI：
10.1177/0961203317693095
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发表时间：
2017-09
期刊：
影响因子：
2.6
通讯作者：
Drenkard C
中科院分区：
文献类型：
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作者：
Plantinga L;Lim SS;Bowling CB;Drenkard C
目的：研究成人系统性红斑狼疮(SLE)患者的认知症状与感知压力的关系。在777名成年(>；18岁)SLE患者中，我们研究了感知压力量表(PSS)得分与两种自我报告的认知症状的相关性：健忘[严重/中度与轻度/无；来自系统性狼疮活动问卷]和难以集中(全部/大部分与部分/很少/无；来自狼疮影响跟踪器；)。我们使用多变量Logistic回归来估计PSS评分和认知症状的每一个最小重要差异(MID=0.5*SD)的优势比(OR)。健忘和注意力难以集中的比例分别为41.7%和29.5%。女性和那些受教育程度较低和疾病活跃度较高的人比她们的同龄人有更高的PSS评分，更有可能报告认知症状。在调整了年龄、种族、性别、教育程度和疾病活动后，PSS评分每增加一次，健忘率(OR=1.43，95%CI为1.29~1.47)和注意力难以集中(OR=2.19，95%CI为1.90~2.52)的患病率均较高。这种关联在年龄、种族、性别或疾病活动方面没有显著差异。系统性红斑狼疮患者，特别是那些疾病活动性高的患者，报告了高认知症状负担，对这些症状来说，压力可能是一个可改变的风险因素。
To examine associations of perceived stress with cognitive symptoms among adults with systemic lupus erythematosus (SLE). Among 777 adult (>18 years) SLE patients, we examined the association of Perceived Stress Scale (PSS) scores with two self-reported cognitive symptoms: forgetfulness [severe/moderate vs. mild/none; from the Systemic Lupus Activity Questionnaire] and difficulty concentrating (all/most vs. some/little/none of the time; from the Lupus Impact Tracker). We used multivariable logistic regression to estimate the odds ratios (ORs) per minimal important difference (MID=0.5*SD) of PSS score and cognitive symptoms. Forgetfulness and difficulty concentrating were reported by 41.7% and 29.5%, respectively. Women and those with less education and high disease activity had higher PSS scores and were more likely to report cognitive symptoms than their counterparts. With adjustment for age, race, sex, education, and disease activity, each MID increase in PSS score was associated with higher prevalence of forgetfulness (OR=1.43, 95% CI 1.29–1.47) and difficulty concentrating (OR=2.19, 95% CI 1.90–2.52). No substantial differences in this association by age, race, sex, or disease activity were noted. SLE patients, particularly those with high disease activity, report a high burden of cognitive symptoms, for which stress may be a modifiable risk factor.