Staphylococcus cohnii is a potentially biotherapeutic skin commensal alleviating skin inflammation
Staphylococcus cohnii is a potentially biotherapeutic skin commensal alleviating skin inflammation
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DOI：
10.1016/j.celrep.2021.109052
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发表时间：
2021-04-27
期刊：
影响因子：
8.8
通讯作者：
Honda, Kenya
中科院分区：
文献类型：
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作者：
Ito, Yoshihiro;Sasaki, Takashi;Honda, Kenya
宿主-微生物相互作用协调皮肤内稳态，其失调已涉及慢性炎症性病症，如特应性皮炎和牛皮癣。在这里，我们表明，葡萄球菌cohnii是一种皮肤真菌能够有益地抑制皮肤炎症。我们发现，Tmem 79（-/-）小鼠自发发展白细胞介素-17（IL-17）产生T细胞驱动的皮肤炎症。比较皮肤微生物组分析显示，疾病活动指数与S。科尼。接种S.从小鼠或人皮肤微生物群分离的cohnii菌株显著预防和改善Tmem 79（-/-）小鼠的皮炎，而不影响致病菌负荷。S. Cohnii定殖伴随着宿主糖皮质激素相关途径的激活和皮肤中抗炎基因的诱导，因此在多种病原体非依赖性皮炎模型中有效抑制炎症，包括化学诱导的、17型和2型免疫驱动模型。因此，S. Cohnii菌株具有作为皮肤炎症的有效活生物治疗剂的巨大潜力。
Host-microbe interactions orchestrate skin homeostasis, the dysregulation of which has been implicated in chronic inflammatory conditions such as atopic dermatitis and psoriasis. Here, we show that Staphylococcus cohnii is a skin commensal capable of beneficially inhibiting skin inflammation. We find that Tmem79(-/-) mice spontaneously develop interleukin-17 (IL-17)-producing T-cell-driven skin inflammation. Comparative skin microbiome analysis reveals that the disease activity index is negatively associated with S. cohnii. Inoculation with S. cohnii strains isolated from either mouse or human skin microbiota significantly prevents and ameliorates dermatitis in Tmem79(-/-) mice without affecting pathobiont burden. S. cohnii colonization is accompanied by activation of host glucocorticoid-related pathways and induction of anti-inflammatory genes in the skin and is therefore effective at suppressing inflammation in diverse pathobiont-independent dermatitis models, including chemically induced, type 17, and type 2 immune-driven models. As such, S. cohnii strains have great potential as effective live biotherapeutics for skin inflammation.