The Significance of Serum Xanthine Oxidoreductase in Patients with Nonalcoholic Fatty Liver Disease
The Significance of Serum Xanthine Oxidoreductase in Patients with Nonalcoholic Fatty Liver Disease
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DOI：
10.7754/clin.lab.2013.130516
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发表时间：
2014-01-01
影响因子：
0.7
通讯作者：
Chen, Yu
中科院分区：
文献类型：
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作者：
Zhang, Juanwen;Xu, Chengfu;Chen, Yu
背景：血清尿酸水平与非酒精性脂肪性肝病（NAFLD）显著相关。黄嘌呤氧化还原酶（XOR）是催化尿酸形成的关键酶。为探讨血清XOR活性与NAFLD的关系，采用酶联免疫吸附法（ELISA）检测了129例NAFLD患者和71例健康对照者血清XOR活性，结果：NAFLD患者血清XOR活性明显高于健康对照者（P < 0.001）。血清XOR活性与肝损伤标志物和氧化应激指标呈正相关。此外，高XOR活性的患者有更高的代谢综合征患病率。结论：这些数据表明，血清XOR活性与NAFLD显着相关。
Background: Serum uric acid levels are significantly associated with nonalcoholic fatty liver disease (NAFLD). Xanthine oxidoreductase (XOR) is the key enzyme that catalyzes the formation of uric acid. The aim of this study was to investigate the association between serum XOR activity and NAFLD.Methods: In this cross-sectional study, serum XOR activity was measured by enzyme-linked immunosorbent assay in 129 patients with NAFLD and 71 controls.Results: Serum XOR activity was markedly higher in patients with NAFLD than in the controls (p < 0.001). Serum XOR activity positively correlated with markers of liver injury and indices of oxidative stress. Moreover, patients with high XOR activity had a higher prevalence of metabolic syndrome.Conclusions: These data show that serum XOR activity is significantly associated with NAFLD.