Nanotransducer-Enabled Deep-Brain Neuromodulation with NIR-II Light
Nanotransducer-Enabled Deep-Brain Neuromodulation with NIR-II Light
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DOI：
10.1021/acsnano.2c12068
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发表时间：
2023-04-20
期刊：
影响因子：
17.1
通讯作者：
Hong，Guosong
中科院分区：
文献类型：
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作者：
Wu，Xiang;Yang，Fan;Hong，Guosong
第二个近红外窗口(NIR-II窗口)的波长范围从1000到1700 nm，与可见光光谱相比，它显示出减少光散射从而深入生物组织的独特优势。在过去的十年中，NIR-II窗口已被广泛应用于深层组织荧光成像。最近，在NIR-II窗口中，通过利用纳米换能器，可以有效地将大脑穿透性NIR-II光转换为热，证明了大脑深层神经调节。在这一视角下，我们讨论了这种NIR-II深部神经调制技术的原理和潜在的应用，以及与其他现有的光学方法相比的优势和局限性。我们还指出了材料科学和生物工程的进步可以扩展NIR-II神经调节方法的能力和用途的几个未来方向。
The second near-infrared window (NIR-II window), which ranges from 1000 to 1700 nm in wavelength, exhibits distinctive advantages of reduced light scattering and thus deep penetration in biological tissues in comparison to the visible spectrum. The NIR-II window has been widely employed for deep-tissue fluorescence imaging in the past decade. More recently, deep-brain neuromodulation has been demonstrated in the NIR-II window by leveraging nanotransducers that can efficiently convert brain-penetrant NIR-II light into heat. In this Perspective, we discuss the principles and potential applications of this NIR-II deep-brain neuromodulation technique, together with its advantages and limitations compared with other existing optical methods for deep-brain neuromodulation. We also point out a few future directions where the advances in materials science and bioengineering can expand the capability and utility of NIR-II neuromodulation methods.