The prognostic significance of RCAS1 expression in squamous cell carcinoma of the oesophagus
The prognostic significance of RCAS1 expression in squamous cell carcinoma of the oesophagus
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DOI：
10.1016/s0304-3835(01)00773-x
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发表时间：
2002-03-08
期刊：
影响因子：
9.7
通讯作者：
Katoh, H
中科院分区：
文献类型：
--
作者：
Nakakubo, Y;Hida, Y;Katoh, H
RCAS1（SiSo细胞上表达的受体结合癌抗原）的过表达可保护癌细胞免受免疫攻击，并可能与几种癌症的预后不良有关。我们研究了95例手术切除的食管鳞状细胞癌患者中RCAS1的免疫反应性及其与临床病理特征的相关性。95例中有32例（33.7%）RCAS1强阳性。RCAS1与年龄和分期分组有显著相关性。RCAS1表达与术后生存期缩短相关。多因素分析显示RCAS1阳性是独立的负性预后因素。我们的研究确立了RCAS1作为手术切除的食管鳞状细胞癌的一种新的预后标志物。(C)2002爱思唯尔科学爱尔兰有限公司保留所有权利。
Overexpression of RCAS1 (receptor-binding cancer antigen expressed on SiSo cells) protects cancer cells from immune attack and might be related to poor prognosis in several cancers. We investigated the immunoreactivity of RCAS1 and its correlation with clinicopathological features in 95 patients who underwent surgical resection for oesophageal squamous cell carcinoma. Thirty-two of the 95 (33.7%) cases were strongly positive for RCAS1. RCAS1 showed significant correlations with age and stage grouping. Expression of RCAS1 was associated with shorter postoperative survival. Multivariate analysis indicated that RCAS1 positivity was an independent negative prognostic factor. Our study establishes RCAS1 as a novel prognostic marker for surgically resected oesophageal squamous cell carcinoma. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.