Nationwide hepatitis B vaccination program in Taiwan: Effectiveness in the 20 years after it was launched
Nationwide hepatitis B vaccination program in Taiwan: Effectiveness in the 20 years after it was launched
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DOI：
10.1093/epirev/mxj010
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发表时间：
2006-01-01
影响因子：
5.5
通讯作者：
Chen, Chien-Jen
中科院分区：
文献类型：
--
作者：
Chien, Yin-Chu;Jan, Chyi-Feng;Chen, Chien-Jen
台湾的国家乙肝疫苗接种计划被认为是过去20年来控制慢性乙肝感染最成功和有效的公共卫生计划之一。本文以台湾的经验为基础，说明如何成功实施乙型肝炎疫苗接种计划。台湾几项重要的乙型肝炎免疫球蛋白和疫苗的随机对照临床试验表明，对乙型肝炎包膜抗原或乙型肝炎表面抗原阳性母亲的婴儿有80-90%的保护作用。对全国预防接种前后出生的儿童进行的一系列患病率调查显示，台湾地区乙型肝炎表面抗原的血清阳性率在全国预防接种计划启动后稳步下降，有效率为78-87%。对肝脏疾病风险长期趋势的研究也表明，在国家疫苗接种计划开始后，婴儿暴发性肝炎死亡率下降68%，6-9岁儿童肝细胞癌发病率下降75%。综上所述，自1984年以来，全国乙肝疫苗接种计划在预防急慢性肝病方面取得了成功。
The national hepatitis B vaccination program in Taiwan is considered one of the most successful and effective public health programs to control chronic hepatitis B infection in the past 20 years. This review illustrates how to implement a successful hepatitis B vaccination program based on Taiwan's experience. Several important controlled randomized clinical trials on hepatitis B immunoglobulin and vaccine in Taiwan demonstrated an 80-90% protective effect among infants of mothers who were positive for either hepatitis B envelope antigen or hepatitis B surface antigen. A series of prevalence surveys on children born before and after the national vaccination program began disclosed a steady decrease in seroprevalence of hepatitis B surface antigen in Taiwan, with 78-87% effectiveness after the national vaccination program was launched. Studies on the secular trend of liver disease risk also documented a 68% decline in mortality from fulminant hepatitis in infants and a 75% decrease in the incidence of hepatocellular carcinoma in children 6-9 years of age after the national vaccination program began. In conclusion, since 1984, the national hepatitis B vaccination program has been successful in preventing acute and chronic liver diseases in Taiwan.