Prefrontal modulation during chewing performance in occlusal dysesthesia patients: a functional near-infrared spectroscopy study
Prefrontal modulation during chewing performance in occlusal dysesthesia patients: a functional near-infrared spectroscopy study
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DOI：
10.1007/s00784-018-2534-7
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发表时间：
2019-03-01
影响因子：
3.4
通讯作者：
Wake, Hiroyuki
中科院分区：
文献类型：
--
作者：
Narita, Noriyuki;Kamiya, Kazunobu;Wake, Hiroyuki
咬合感觉迟钝（OD）患者经常抱怨持续的咬合不适，并且上级内侧前额叶皮层和颞顶叶区域也存在躯体化效应。然而，身体活动之间的关系，即，咀嚼、前额叶认知需求和精神状态在OD患者中的作用尚不清楚。我们在本研究中调查了这种关系。材料和方法OD患者（n=15）和健康对照（n=15; HC）受试者入选本研究。咬合接触，咀嚼肌的咀嚼活动，前额叶活动，以及精神状态，如抑郁和躯体化，的参与者进行了评估。功能性近红外光谱被用来确定前额叶血流动力学和症状自评量表-90-R被用来评分的精神state.ResultsWe观察到一个显着的关联在咀嚼和躯体化分量表OD患者前额叶失活。此外，有没有显着差异，关于咬合状态和咀嚼的身体活动之间的OD患者和HC subject.ConclusionsChewing-related前额钝化可能与躯体化的严重程度在OD patients.Clinical relevancefNIRS是一种功能成像方法，使用的神经血管耦合的原则。适用于基于前额叶皮层血流的精神疾病患者的精神状态评估。
ObjectivesNeuropsychological associations can be considerable in occlusal dysesthesia (OD) patients who routinely complain of persistent occlusal discomfort, and somatization effects in the superior medial prefrontal cortex and the temporal and parietal regions are also present. However, the relationship between physical activity, i.e., chewing, prefrontal cognitive demand, and psychiatric states in OD patients remains unclear. We investigated this relationship in this study.Materials and methodsOD patients (n=15) and healthy control (n=15; HC) subjects were enrolled in this study. Occlusal contact, chewing activities of the masticatory muscles, prefrontal activities, and psychiatric states such as depression and somatization, of the participants were evaluated. Functional near-infrared spectroscopy was used to determine prefrontal hemodynamics and the Symptom Checklist-90-R was used to score the psychiatric states.ResultsWe observed a significant association between prefrontal deactivation during chewing and somatization subscales in OD patients. Further, there were no significant differences with regard to the occlusal state and chewing physical activities between the OD patients and HC subjects.ConclusionsChewing-related prefrontal deactivation may be associated with somatization severity in OD patients.Clinical relevancefNIRS is a functional imaging method that uses the principal of neuro-vascular couplings. It is applicable for evaluation of psychiatric state based on prefrontal cortex blood flow in patients with psychiatric disorders.