INTRAGASTRIC NITRIC-OXIDE PRODUCTION IN HUMANS - MEASUREMENTS IN EXPELLED AIR
INTRAGASTRIC NITRIC-OXIDE PRODUCTION IN HUMANS - MEASUREMENTS IN EXPELLED AIR
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DOI：
10.1136/gut.35.11.1543
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发表时间：
1994-11-01
期刊：
影响因子：
24.5
通讯作者：
ALVING, K
中科院分区：
文献类型：
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作者：
LUNDBERG, JON;WEITZBERG, E;ALVING, K
用化学发光技术显示，人体胃排出的空气中的一氧化氮(NO)含量很高(800-6000 ppb)。这些NO值比口腔呼出的空气中的值高出100多倍。胃内NO的产生可能是非酶促的，需要酸性环境，因为质子泵抑制剂奥美拉唑预处理后，排出的空气中的NO减少了95%。此外，当将生菜和唾液置于氯化氢(pH<；2)中时，在体外可以生成大量的NO。总之，人在胃内形成了大量的NO，这种NO的来源对于健康和疾病中胃粘膜的完整性可能是重要的；测量排出的空气中的NO作为一种无创的方法来估计胃酸可能是有价值的。
High values (800-6000 parts per billion) of nitric oxide (NO) in expelled air from the stomach were shown in humans by chemiluminescence technique. These NO values were more than 100 times higher than those found in orally exhaled air. Intragastric NO production is probably non-enzymatic, requiring an acidic environment, as NO in expelled air was reduced by 95% after pretreatment with the proton pump inhibitor omeprazole. Furthermore, large amounts of NO were formed in vitro from lettuce and saliva when placed in hydrogen chloride (pH < 2). In conclusion, large amounts of NO are formed intragastrically in humans and this source of NO may be of importance for the integrity of the gastric mucosa in health and disease; Measurements of NO in expelled air might be of value as a non-invasive method for estimation of gastric acidity.