Characterization of human immunodeficiency virus type 1 (HIV-1) envelope variation and neutralizing antibody responses during transmission of HIV-1 subtype B
Characterization of human immunodeficiency virus type 1 (HIV-1) envelope variation and neutralizing antibody responses during transmission of HIV-1 subtype B
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DOI：
10.1128/jvi.79.10.6523-6527.2005
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发表时间：
2005-05-01
影响因子：
5.4
通讯作者：
Richman, DD
中科院分区：
文献类型：
--
作者：
Frost, SDW;Liu, Y;Richman, DD
我们分析了中和敏感性和遗传变异的传播亚型B人类免疫缺陷病毒1型（HIV-1）在8个最近感染的男性谁与男性发生性关系和病毒从6个受试者谁感染他们。相反，报告的异性传播的亚型C HIV-1，其中传播的病毒似乎是更中和敏感，我们证明，在我们的研究人群中，相对较少的表型变化中和敏感性或基因型变化的信封发生在传播亚型B HIV-1。我们认为，感染宿主内有限的遗传变异降低了选择性传播中和敏感型HIV的可能性。
We analyzed neutralization sensitivity and genetic variation of transmitted subtype B human immunodeficiency virus type 1 (HIV-1) in eight recently infected men who have sex with men and the virus from the six subjects who infected them. In contrast to reports of heterosexual transmission of subtype C HIV-1, in which the transmitted virus appears to be more neutralization sensitive, we demonstrate that in our study population, relatively few phenotypic changes in neutralization sensitivity or genotypic changes in envelope occurred during transmission of subtype B HIV-1. We suggest that limited genetic variation within the infecting host reduces the likelihood of selective transmission of neutralization-sensitive HIV.