The association between tumor's location and cervical lymph nodes metastasis in papillary thyroid cancer
The association between tumor's location and cervical lymph nodes metastasis in papillary thyroid cancer
复制标题
甲状腺乳头状癌肿瘤部位与颈部淋巴结转移的关系
DOI：
10.21037/gs.2019.10.02
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发表时间：
2019-10-01
期刊：
影响因子：
1.8
通讯作者：
Qu, Ning
中科院分区：
文献类型：
--
作者：
Zhang, Ting-Ting;Qi, Xiu-Zhu;Qu, Ning
背景：甲状腺乳头状癌（PTC）有很强的转移到颈部淋巴结的倾向。目前对于肿瘤的位置是否会影响PTC的淋巴结转移风险知之甚少。方法：本研究纳入了在我中心接受原发性单灶性小肿瘤手术治疗的PTC患者。超声在三轴、三平面和三维空间中评估肿瘤的位置。采用Logistic单因素和多因素分析探讨PTC患者肿瘤部位与淋巴结转移风险的关系。采用ROC曲线对不同的甲状腺肿瘤定位方法进行评价。结果：共有1266例PTC患者入组。单因素和多因素分析显示，性别、年龄、肿瘤大小和肿瘤位置（纵轴、纵矢状面、纵冠状面、矢状冠状面和三维空间）与中央淋巴结清扫（CLND）有关；性别、肿瘤大小、肿瘤位置（纵轴、冠状轴、纵矢状面、纵冠状面、矢状冠状面和三维空间）与侧淋巴结清扫（LLND）相关（P . 1）
Background: Papillary thyroid cancer (PTC) has a strong propensity to metastasize to the cervical lymph nodes. Little was known currently about whether tumor's location would influence the risk of lymph node metastasis in PTC.Methods: The study enrolled PTC patients who underwent primary surgical therapy in our center for small unifocal tumor. The tumor's location was evaluated by ultrasound in three axes, three planes and 3D space. Logistic univariate and multivariate analysis were applied to explore the association between tumors' location and the risk of lymph node metastasis in PTC. Different localization methods of thyroid tumors were evaluated using ROC curve.Results: Totally 1,266 PTC patients were enrolled in this study. Univariate and multivariate analyses showed that gender, age, tumor size and tumor's location (in longitudinal axis, longitudinal sagittal plane, longitudinal coronal plane, sagittal coronal plane and 3D space) was associated with central lymph node dissection (CLND); gender, tumor size and tumor's location (in longitudinal axis, coronal axis, longitudinal sagittal plane, longitudinal coronal plane, sagittal coronal plane and 3D space) was related with lateral lymph node dissection (LLND) (P